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Details on Person UniProt:Q0GUM3 Gm12250
| Class:Id | ReferenceGeneProduct:9834102 |
|---|---|
| _chainChangeLog | initiator methionine:1 for 9834102 added on Fri May 5 2023;chain:2-417 for 9834102 added on Fri May 5 2023;initiator methionine:1 for 9834102 removed on Fri Nov 03 2023;initiator methionine: for 9834102 added on Fri Nov 03 2023;initiator methionine: for 9834102 removed on Fri Aug 15 2025;initiator methionine:1 for 9834102 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q0GUM3 Gm12250 |
| _timestamp | 2025-08-15 21:15:45 |
| chain | initiator methionine:1 chain:2-417 |
| checksum | C43A27660835EB6F |
| comment | FUNCTION Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens by mediating cytosolic release of pathogenic ligands that activate the inflammasomes (PubMed:16959883, PubMed:20109161, PubMed:27693356, PubMed:30062052, PubMed:30510167, PubMed:34694641). Following infection, recruited to the membrane of pathogens in a GBP-dependent manner and mediates disruption of the pathogen membrane, liberating ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:27693356, PubMed:30062052, PubMed:30510167). Promotes AIM2 and NLRP3 inflammasome activation following A.fumigatus infection by liberating beta-glucan, which directly triggers inflammasome assembly (PubMed:30510167). Promotes NLRP3 inflammasome activation following influenza A virus infection (PubMed:34694641).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)SUBUNIT Homooligomer; homooligomerization occurs upon GTP-binding and is required for the association with membranous structures (PubMed:23785284, PubMed:27693356). Homodimer; GDP-binding induces formation of an inactive head-to-head homodimer (PubMed:33469160).SUBCELLULAR LOCATION Recruited to the membrane of pathogens in the cytosol in a GBP (Gbp1, Gbp2, Gbp3, Gbp5 ad/or Gbp7)-dependent manner (PubMed:27693356). Recruited to the membrane of pathogen-containing vacuoles: vacuoles may serve as a cellular transport mechanism to deliver Gm12250/Irgb10 to the pathogen membrane (Probable) (PubMed:23785284, PubMed:27693356).INDUCTION By IFNG/IFN-gamma (PubMed:16959883). Induced by IRF1 in response to bacterial infection (PubMed:27693356).PTM Myristoylation is required for localization to pathogen-containing vacuoles (PubMed:23785284).PTM (Microbial infection) Phosphorylated by Toxoplasma gondii ROP18.SIMILARITY Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily. |
| created | [InstanceEdit:9834092] Weiser, Joel |
| description | recommendedName: fullName evidence="12"Interferon-gamma-inducible GTPase 10 shortName evidence="12"Irgb10 ecNumber evidence="10"3.6.5.- |
| geneName | Gm12250 Irgb10 |
| identifier | Q0GUM3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasmic vesicle GTP-binding Hydrolase Immunity Innate immunity Lipoprotein Membrane Myristate Nucleotide-binding Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Gm12250 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IRB10_MOUSE Q0GUM2 |
| sequenceLength | 417 |
| species | [Species:48892] Mus musculus |
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No pathways have been reviewed or authored by UniProt:Q0GUM3 Gm12250 (9834102)
