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Details on Person L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs

Class:Id	BlackBoxEvent:9834003
_displayName	L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs
_doRelease	TRUE
_timestamp	2023-11-09 15:46:01
authored	[InstanceEdit:9834002] Orlic-Milacic, Marija, 2023-05-05
catalystActivity	[CatalystActivity:9834007] methyltransferase cap1 activity of RSV m7GpppG-mRNAs:RdRP:p-M2-1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9834002] Orlic-Milacic, Marija, 2023-05-05
disease	[Disease:9833927] respiratory syncytial virus infectious disease
edited	[InstanceEdit:9853005] Orlic-Milacic, Marija, 2023-11-09
input	[SimpleEntity:9639461] S-adenosyl-L-methionine [cytosol] [Complex:9834005] RSV m7GpppG-mRNAs:RdRP:p-M2-1 [cytosol] [Human respiratory syncytial virus A]
isChimeric	FALSE
literatureReference	[LiteratureReference:9834741] Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase [LiteratureReference:9834866] The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2'-O-methylation
modified	[InstanceEdit:9834776] Orlic-Milacic, Marija, 2023-05-10 [InstanceEdit:9834873] Orlic-Milacic, Marija, 2023-05-10 [InstanceEdit:9837754] Orlic-Milacic, Marija, 2023-06-17 [InstanceEdit:9838751] Orlic-Milacic, Marija, 2023-06-26 [InstanceEdit:9850763] Orlic-Milacic, Marija, 2023-10-12 [InstanceEdit:9851919] Orlic-Milacic, Marija, 2023-11-02 [InstanceEdit:9852855] Orlic-Milacic, Marija, 2023-11-07 [InstanceEdit:9853009] Orlic-Milacic, Marija, 2023-11-09
name	L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs
output	[SimpleEntity:9639443] S-adenosyl-L-homocysteine [cytosol] [Complex:9834001] RSV m7G(5')pppGm-mRNAs:RdRP:p-M2-1 [cytosol] [Human respiratory syncytial virus A]
precedingEvent	[BlackBoxEvent:9830848] L protein acts as a cap N7 methyltransferase to modify RSV mRNAs [Homo sapiens] [BlackBoxEvent:9828639] Transcription of respiratory syncytial virus subgenomic positive sense mRNAs [Homo sapiens]
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9834011] R-HSA-9834003.1
summation	[Summation:9834689] 5' capping of respiratory syncytial virus (RSV) mRNAs is cat...
(hasEvent)	[Pathway:9828642] Respiratory syncytial virus genome transcription [Homo sapiens]
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No pathways have been reviewed or authored by L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs (9834003)