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Details on Person ISGylation of PKR

Class:IdBlackBoxEvent:9833973
_displayNameISGylation of PKR
_doReleaseTRUE
_timestamp2025-01-29 09:13:45
authored[InstanceEdit:9833963] Stephan, Ralf, 2023-05-05
catalystActivity[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9833966] Stephan, Ralf, 2023-05-05
edited[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9833429] Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation
modified[InstanceEdit:9834828] Stephan, Ralf, 2023-05-10
[InstanceEdit:9834874] Stephan, Ralf, 2023-05-10
[InstanceEdit:9835124] Stephan, Ralf, 2023-05-11
[InstanceEdit:9841795] Matthews, Lisa, 2023-08-14
[InstanceEdit:9841952] Stephan, Ralf, 2023-08-16
[InstanceEdit:9842154] Stephan, Ralf, 2023-08-21
[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
nameISGylation of PKR
output[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens]
[CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens]
[CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens]
[CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
[Complex:9833969] ISG15-EIF2AK2 dimer [cytosol] [Homo sapiens]
precedingEvent
releaseDate2023-09-13
reviewed[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9833974] R-HSA-9833973.2
structureModified[InstanceEdit:9834874] Stephan, Ralf, 2023-05-10
summation[Summation:9834804] PKR (EIF2AK2) is modified by ISG15 ligase complex on lysine ...
(hasEvent)[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
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No pathways have been reviewed or authored by ISGylation of PKR (9833973)