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Details on Person ISGylation of PKR
Class:Id BlackBoxEvent:9833973
_displayName ISGylation of PKR
_doRelease TRUE
_timestamp 2025-01-29 09:13:45
authored [InstanceEdit:9833963] Stephan, Ralf, 2023-05-05
catalystActivity [CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
compartment [Compartment:70101] cytosol
created [InstanceEdit:9833966] Stephan, Ralf, 2023-05-05
edited [InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens] [Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens] [Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens] [Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:9833429] Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation
modified [InstanceEdit:9834828] Stephan, Ralf, 2023-05-10 [InstanceEdit:9834874] Stephan, Ralf, 2023-05-10 [InstanceEdit:9835124] Stephan, Ralf, 2023-05-11 [InstanceEdit:9841795] Matthews, Lisa, 2023-08-14 [InstanceEdit:9841952] Stephan, Ralf, 2023-08-16 [InstanceEdit:9842154] Stephan, Ralf, 2023-08-21 [InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name ISGylation of PKR
output [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:111294] PPi [cytosol] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens] [Complex:9833969] ISG15-EIF2AK2 dimer [cytosol] [Homo sapiens]
precedingEvent
releaseDate 2023-09-13
reviewed [InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9833974] R-HSA-9833973.2
structureModified [InstanceEdit:9834874] Stephan, Ralf, 2023-05-10
summation [Summation:9834804] PKR (EIF2AK2) is modified by ISG15 ligase complex on lysine ...
(hasEvent) [Pathway:9833482] PKR-mediated signaling [Homo sapiens]
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No pathways have been reviewed or authored by ISGylation of PKR (9833973)