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Details on Person PKR forms a dimer

Class:IdReaction:9833723
_displayNamePKR forms a dimer
_doReleaseTRUE
_timestamp2025-01-29 09:14:54
authored[InstanceEdit:9833621] Stephan, Ralf, 2023-05-02
compartment[Compartment:70101] cytosol
created[InstanceEdit:9833724] Stephan, Ralf, 2023-05-03
edited[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9833722] Activation of PKR: an open and shut case?
[LiteratureReference:9833728] Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition
[LiteratureReference:9833553] Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR
[LiteratureReference:9833780] Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR)
[LiteratureReference:9834842] Regulation of PKR by RNA: formation of active and inactive dimers
[LiteratureReference:9841956] The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo
modified[InstanceEdit:9833742] Stephan, Ralf, 2023-05-03
[InstanceEdit:9834828] Stephan, Ralf, 2023-05-10
[InstanceEdit:9835124] Stephan, Ralf, 2023-05-11
[InstanceEdit:9835192] Stephan, Ralf, 2023-05-12
[InstanceEdit:9835318] Stephan, Ralf, 2023-05-13
[InstanceEdit:9835340] Stephan, Ralf, 2023-05-13
[InstanceEdit:9835377] Stephan, Ralf, 2023-05-14
[InstanceEdit:9835390] Stephan, Ralf, 2023-05-14
[InstanceEdit:9835438] Stephan, Ralf, 2023-05-15
[InstanceEdit:9835455] Stephan, Ralf, 2023-05-15
[InstanceEdit:9835967] Stephan, Ralf, 2023-05-22
[InstanceEdit:9836610] Stephan, Ralf, 2023-05-31
[InstanceEdit:9836679] Stephan, Ralf, 2023-06-01
[InstanceEdit:9836817] Stephan, Ralf, 2023-06-02
[InstanceEdit:9839011] Stephan, Ralf, 2023-06-29
[InstanceEdit:9839031] Stephan, Ralf, 2023-06-29
[InstanceEdit:9841795] Matthews, Lisa, 2023-08-14
[InstanceEdit:9841952] Stephan, Ralf, 2023-08-16
[InstanceEdit:9841967] Stephan, Ralf, 2023-08-16
[InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
namePKR forms a dimer
output[Complex:9833725] EIF2AK2 dimer [cytosol] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9839010] Positive regulation by 'EIF2AK2 dimer:Viral RNA activators [cytosol]'
[PositiveRegulation:9833813] Positive regulation by 'EIF2AK2 dimer:Host RNA activators [cytosol]'
[PositiveRegulation:9833971] Positive regulation by 'ISG15-EIF2AK2 dimer [cytosol]'
[PositiveRegulation:9834833] Positive regulation by 'SUMO-EIF2AK2 dimer [cytosol]'
[PositiveRegulation:9834817] Positive regulation by 'p-PRKRA:EIF2AK2 dimer [cytosol]'
[PositiveRegulation:9834790] Positive regulation by 'ILF3:EIF2AK2 dimer [cytosol]'
[PositiveRegulation:9835113] Positive regulation by 'EIF2AK2 dimer:heparin [cytosol]'
[NegativeRegulation:9835195] Negative regulation by 'EIF2AK2:NCK1 [cytosol]'
[NegativeRegulation:9835319] Negative regulation by 'NPM1:EIF2AK2 [cytosol]'
[NegativeRegulation:9835339] Negative regulation by 'p-TARBP2:EIF2AK2 [cytosol]'
[NegativeRegulation:9835387] Negative regulation by 'DUS2:EIF2AK2 [cytosol]'
[NegativeRegulation:9835397] Negative regulation by 'FA Core Complex:HSP70s:EIF2AK2 [cytosol]'
[NegativeRegulation:9835445] Negative regulation by 'STAT1,STAT3:EIF2AK2 [cytosol]'
[NegativeRegulation:9835461] Negative regulation by 'DNAJC3:EIF2AK2 [cytosol]'
[NegativeRegulation:9835965] Negative regulation by 'tat72:EIF2AK2 [cytosol]'
[NegativeRegulation:9835958] Negative regulation by 'EIF2AK2:VTRNA2-1 [cytosol]'
[NegativeRegulation:9835942] Negative regulation by 'NS1 Homodimer:PKR Complex [cytosol]'
[NegativeRegulation:9835910] Negative regulation by 'EIF2AK2:N [cytosol]'
[NegativeRegulation:9835968] Negative regulation by 'ADAR1 dimer:EIF2AK2 [cytosol]'
[NegativeRegulation:9836605] Negative regulation by 'EIF2AK2:p-SPHK1 [cytosol]'
[NegativeRegulation:9836687] Negative regulation by 'EIF2AK2:PKR inhibitors [cytosol]'
[NegativeRegulation:9839030] Negative regulation by 'EIF2AK2:HIV TAR RNA [cytosol]'
regulationReference[RegulationReference:9833828] Positive regulation by 'EIF2AK2 dimer:RNA activators [cytosol]' The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators
[RegulationReference:9833972] Positive regulation by 'ISG15-EIF2AK2 dimer [cytosol]' Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation
[RegulationReference:9834799] Positive regulation by 'SUMO-EIF2AK2 dimer [cytosol]' Activation of the double-stranded RNA-dependent protein kinase PKR by small ubiquitin-like modifier (SUMO)
[RegulationReference:9834845] Positive regulation by 'p-PRKRA:EIF2AK2 [cytosol]' PACT, a protein activator of the interferon-induced protein kinase, PKR
[RegulationReference:9834805] Positive regulation by 'ILF3:EIF2AK2 [cytosol]' Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase
[RegulationReference:9835120] Positive regulation by 'EIF2AK2 dimer:heparin [cytosol]' Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase
[RegulationReference:9835188] Negative regulation by 'EIF2AK2:NCK1 [cytosol]' Nck-1 interacts with PKR and modulates its activation by dsRNA
[RegulationReference:9835323] Negative regulation by 'NPM1:EIF2AK2 [cytosol]' Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR
[RegulationReference:9835343] Negative regulation by 'p-TARBP2:EIF2AK2 [cytosol]' Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation
[RegulationReference:9835386] Negative regulation by 'DUS2:EIF2AK2 [cytosol]' Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR
[RegulationReference:9835413] Negative regulation by 'FA Core Complex:HSP70s:EIF2AK2 [cytosol]' The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC
[RegulationReference:9835449] Negative regulation by 'STAT3:EIF2AK2 [cytosol]' Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity
[RegulationReference:9835456] Negative regulation by 'DNAJC3:EIF2AK2 [cytosol]' Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function
[RegulationReference:9835962] Negative regulation by 'tat72:EIF2AK2 [cytosol]' HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms
[RegulationReference:9835952] Negative regulation by 'EIF2AK2:VTRNA2-1 [cytosol]' Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR
[RegulationReference:9835883] Negative regulation by 'NS1 Homodimer:PKR Complex [cytosol]' Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR
[RegulationReference:9835881] Negative regulation by 'ADAR1 dimer:EIF2AK2 [cytosol]' Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection
[RegulationReference:9835878] Negative regulation by 'EIF2AK2:N [cytosol]' Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication
[RegulationReference:9836607] Negative regulation by 'EIF2AK2:p-SPHK1 [cytosol]' Cell fate determined by the activation balance between PKR and SPHK1
[RegulationReference:9836694] Negative regulation by 'EIF2AK2:PKR inhibitors [cytosol]' Inhibition of RNA-binding proteins with small molecules
[RegulationReference:9839029] Negative regulation by 'EIF2AK2:HIV TAR RNA [cytosol]' Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase
releaseDate2023-09-13
reviewed[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9833729] R-HSA-9833723.2
structureModified[InstanceEdit:9834828] Stephan, Ralf, 2023-05-10
[InstanceEdit:9835124] Stephan, Ralf, 2023-05-11
[InstanceEdit:9835192] Stephan, Ralf, 2023-05-12
[InstanceEdit:9835318] Stephan, Ralf, 2023-05-13
[InstanceEdit:9835340] Stephan, Ralf, 2023-05-13
[InstanceEdit:9835377] Stephan, Ralf, 2023-05-14
[InstanceEdit:9835390] Stephan, Ralf, 2023-05-14
[InstanceEdit:9835438] Stephan, Ralf, 2023-05-15
[InstanceEdit:9835455] Stephan, Ralf, 2023-05-15
[InstanceEdit:9835967] Stephan, Ralf, 2023-05-22
[InstanceEdit:9836610] Stephan, Ralf, 2023-05-31
[InstanceEdit:9836679] Stephan, Ralf, 2023-06-01
[InstanceEdit:9836817] Stephan, Ralf, 2023-06-02
[InstanceEdit:9839011] Stephan, Ralf, 2023-06-29
[InstanceEdit:9839031] Stephan, Ralf, 2023-06-29
summation[Summation:9833726] PKR (EIF2AK2) exists in a weak monomer/dimer equilibrium and...
(hasEvent)[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
(precedingEvent)[Reaction:9833820] PKR dimer autophosphorylates [Homo sapiens]
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No pathways have been reviewed or authored by PKR forms a dimer (9833723)
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