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Details on Person Diagram of PKR-mediated signaling
| Class:Id | PathwayDiagram:9833645 |
|---|---|
| _displayName | Diagram of PKR-mediated signaling |
| _timestamp | 2023-11-09 09:39:47 |
| created | [InstanceEdit:9833646] Stephan, Ralf, 2023-05-02 |
| height | 2132 |
| modified | [InstanceEdit:9833724] Stephan, Ralf, 2023-05-03 [InstanceEdit:9833742] Stephan, Ralf, 2023-05-03 [InstanceEdit:9833827] Stephan, Ralf, 2023-05-04 [InstanceEdit:9833963] Stephan, Ralf, 2023-05-05 [InstanceEdit:9833966] Stephan, Ralf, 2023-05-05 [InstanceEdit:9834828] Stephan, Ralf, 2023-05-10 [InstanceEdit:9834874] Stephan, Ralf, 2023-05-10 [InstanceEdit:9834875] Stephan, Ralf, 2023-05-10 [InstanceEdit:9835124] Stephan, Ralf, 2023-05-11 [InstanceEdit:9835192] Stephan, Ralf, 2023-05-12 [InstanceEdit:9835198] Stephan, Ralf, 2023-05-12 [InstanceEdit:9835218] Stephan, Ralf, 2023-05-12 [InstanceEdit:9835318] Stephan, Ralf, 2023-05-13 [InstanceEdit:9835340] Stephan, Ralf, 2023-05-13 [InstanceEdit:9835377] Stephan, Ralf, 2023-05-14 [InstanceEdit:9835390] Stephan, Ralf, 2023-05-14 [InstanceEdit:9835427] Stephan, Ralf, 2023-05-14 [InstanceEdit:9835438] Stephan, Ralf, 2023-05-15 [InstanceEdit:9835455] Stephan, Ralf, 2023-05-15 [InstanceEdit:9835967] Stephan, Ralf, 2023-05-22 [InstanceEdit:9835998] Stephan, Ralf, 2023-05-22 [InstanceEdit:9835999] Stephan, Ralf, 2023-05-22 [InstanceEdit:9836170] Stephan, Ralf, 2023-05-24 [InstanceEdit:9836178] Stephan, Ralf, 2023-05-24 [InstanceEdit:9836320] Stephan, Ralf, 2023-05-26 [InstanceEdit:9836330] Stephan, Ralf, 2023-05-26 [InstanceEdit:9836352] Stephan, Ralf, 2023-05-26 [InstanceEdit:9836394] Stephan, Ralf, 2023-05-27 [InstanceEdit:9836412] Stephan, Ralf, 2023-05-27 [InstanceEdit:9836445] Stephan, Ralf, 2023-05-28 [InstanceEdit:9836457] Stephan, Ralf, 2023-05-28 [InstanceEdit:9836465] Stephan, Ralf, 2023-05-28 [InstanceEdit:9836508] Stephan, Ralf, 2023-05-29 [InstanceEdit:9836512] Stephan, Ralf, 2023-05-30 [InstanceEdit:9836545] Stephan, Ralf, 2023-05-30 [InstanceEdit:9836610] Stephan, Ralf, 2023-05-31 [InstanceEdit:9836614] Stephan, Ralf, 2023-05-31 [InstanceEdit:9836623] Stephan, Ralf, 2023-05-31 [InstanceEdit:9836648] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836679] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836710] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836712] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836714] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836716] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836718] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836720] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836721] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836723] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836725] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836726] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836727] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836730] Stephan, Ralf, 2023-06-01 [InstanceEdit:9836817] Stephan, Ralf, 2023-06-02 [InstanceEdit:9837120] Stephan, Ralf, 2023-06-09 [InstanceEdit:9838979] Stephan, Ralf, 2023-06-28 [InstanceEdit:9839011] Stephan, Ralf, 2023-06-29 [InstanceEdit:9839031] Stephan, Ralf, 2023-06-29 [InstanceEdit:9841885] Stephan, Ralf, 2023-08-15 [InstanceEdit:9842102] Matthews, Lisa, 2023-08-17 [InstanceEdit:9842176] Stephan, Ralf, 2023-08-21 [InstanceEdit:9852734] Stephan, Ralf, 2023-11-06 [InstanceEdit:9852988] Stephan, Ralf, 2023-11-09 |
| representedPathway | [Pathway:9833482] PKR-mediated signaling [Homo sapiens] |
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</org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="497" reactomeId="168255" position="365 1554" bounds="300 1531 131 47" textPosition="307 1539" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>Influenza Infection</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="503" reactomeId="162909" position="357 1651" bounds="285 1622 145 59" textPosition="294 1629" lineColor="255 0 0" isForDisease="true" /> <org.gk.render.ProcessNode id="508" reactomeId="9609646" position="1448 1468" bounds="1390 1446 116 44" textPosition="1398 1453" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>HCMV Infection</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="510" reactomeId="9833110" position="365 1873" bounds="318 1847 95 53" textPosition="325 1851" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>RSV-host interactions</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="512" reactomeId="72613" position="1737 1440" bounds="1687 1406 101 69" textPosition="1695 1411"> <Properties> <displayName>Eukaryotic Translation Initiation</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="516" reactomeId="1834949" position="1199 520" bounds="1132 488 135 65" textPosition="1132 491"> <Properties> <displayName>Cytosolic sensors of pathogen-associated DNA</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="518" reactomeId="2559580" position="1930 387" bounds="1853 358 155 59" textPosition="1853 365"> <Properties> <displayName>Oxidative Stress Induced Senescence</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="522" reactomeId="977225" position="2304 758" bounds="2250 735 109 47" textPosition="2259 736"> <Properties> <displayName>Amyloid fiber formation</displayName> </Properties> 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hideComponents="true"> <Properties> <displayName>EIF2AK2 dimer:Viral RNA activators</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="543" reactomeId="913730" position="869 350" bounds="848 339 42 23" textPosition="848 339"> <Properties> <displayName>MAVS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="544" reactomeId="9839022" position="827 1801" bounds="766 1789 123 25" textPosition="770 1792" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EIF2AK2:VTRNA2-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="545" reactomeId="9835923" position="633 1794" bounds="584 1775 99 39" textPosition="600 1783"> <Properties> <displayName>VTRNA2-1</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="548" reactomeId="9839021" position="831 1720" bounds="764 1706 134 28" textPosition="766 1712" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EIF2AK2:HIV TAR RNA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="552" reactomeId="555063" position="718 531" bounds="665 516 106 30" textPosition="669 520"> <Properties> <displayName>unknown protein</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntity id="553" reactomeId="9842175" position="614 1718" bounds="574 1707 81 23" textPosition="585 1701" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>HIV TAR RNA</displayName> </Properties> </org.gk.render.RenderableEntity> </Nodes> <Edges> <org.gk.render.RenderableReaction id="3" reactomeId="9833635" points="1675 976, 1866 1366, 1848 1504, 1823 1580" position="1848 1504" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="29" /> </Inputs> <Outputs> <Output id="354" /> </Outputs> <Properties> <displayName>p-PKR dimer localizes to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8" reactomeId="9833723" points="585 962, 1370 958, 1390 960" position="1370 958" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" stoichiometry="2" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Inhibitors> <Inhibitor id="92" points="880 1005, 1346 1000" /> <Inhibitor id="99" points="879 1088, 1327 1082" /> <Inhibitor id="114" points="893 1167, 1312 1160" /> <Inhibitor id="118" points="874 1237, 1304 1232" /> <Inhibitor id="121" points="890 1322, 1294 1318" /> <Inhibitor id="124" points="883 1420, 1282 1418" /> <Inhibitor id="134" points="889 1488, 1283 1486" /> <Inhibitor id="143" points="876 1652, 1283 1652" /> <Inhibitor id="159" points="891 1576, 1282 1576" /> <Inhibitor id="162" points="896 1929, 1312 1932" /> <Inhibitor id="305" points="874 1864, 1300 1863" /> <Inhibitor id="444" points="883 1990, 1325 1993" /> <Inhibitor id="485" points="910 2067, 1336 2067" /> <Inhibitor id="544" points="892 1800, 1289 1798" /> <Inhibitor id="548" points="901 1719, 1284 1715" /> </Inhibitors> <Activators> <Activator id="26" points="869 733, 1230 783" /> <Activator id="71" points="885 576, 1116 604" /> <Activator id="63" points="962 505, 1072 522" /> <Activator id="47" points="1154 825, 1256 826" /> <Activator id="67" points="897 655, 1177 704" /> <Activator id="91" points="821 415, 1058 478" /> <Activator id="540" points="1017 390" /> </Activators> <Properties> <displayName>PKR forms a dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="9833777" points="661 733, 701 733, 774 729" position="701 733" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="25" points="641 724" /> <Input id="4" stoichiometry="2" points="530 949, 545 790" /> </Inputs> <Outputs> <Output id="26" /> </Outputs> <Activators> <Activator id="537" points="702 760" /> </Activators> <Properties> <displayName>PKR binds activating host RNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="27" reactomeId="9833820" points="1556 962, 1560 963, 1560 962" position="1560 963" lineWidth="1.0"> <Inputs> <Input id="9" points="1456 962" /> <Input id="28" stoichiometry="22" points="1555 921" /> </Inputs> <Outputs> <Output id="29" points="1611 961" /> <Output id="30" stoichiometry="22" points="1592 920" /> </Outputs> <Catalysts> <Catalyst id="9" points="1456 952, 1504 935" /> </Catalysts> <Inhibitors> <Inhibitor id="313" points="1473 1054" /> </Inhibitors> <Properties> <displayName>PKR dimer autophosphorylates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="40" reactomeId="9833973" points="816 820, 815 821, 819 818" position="815 821" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="42" stoichiometry="4" points="700 820" /> <Input id="79" stoichiometry="4" points="745 888" /> <Input id="4" stoichiometry="2" points="552 949" /> </Inputs> <Outputs> <Output id="44" stoichiometry="4" points="945 852" /> <Output id="43" stoichiometry="4" points="907 902" /> <Output id="45" stoichiometry="4" points="862 903" /> <Output id="47" points="1020 823" /> <Output id="46" stoichiometry="4" points="892 794" /> </Outputs> <Catalysts> <Catalyst id="42" points="700 810, 758 800" /> </Catalysts> <Properties> <displayName>ISGylation of PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="81" reactomeId="9834809" points="711 491, 713 492, 743 492" position="713 492" lineWidth="1.0"> <Inputs> <Input id="82" stoichiometry="6" points="669 476" /> <Input id="4" stoichiometry="2" points="529 949, 536 503" /> </Inputs> <Outputs> <Output id="83" stoichiometry="6" points="789 465" /> <Output id="63" points="831 494" /> </Outputs> <Catalysts> <Catalyst id="552" points="716 513" /> </Catalysts> <Properties> <displayName>SUMOylation of PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="9834821" points="699 649, 698 648, 748 645" position="698 648" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" stoichiometry="2" points="528 949, 521 673" /> <Input id="86" points="638 626" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Properties> <displayName>p-PRKRA dimer binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="87" reactomeId="9834807" points="696 569, 696 571, 754 570" position="696 571" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" stoichiometry="2" points="529 949, 544 589" /> <Input id="88" points="609 547" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> <Properties> <displayName>ILF3 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="89" reactomeId="9835121" points="646 410, 648 407, 723 405" position="648 407" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="90" points="596 382" /> <Input id="4" stoichiometry="2" points="528 949, 528 477" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Properties> <displayName>Heparin binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="93" reactomeId="9835189" points="678 1004, 678 1006, 779 1006" position="678 1006" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="94" points="637 1018" /> <Input id="4" points="570 978" /> </Inputs> <Outputs> <Output id="92" /> </Outputs> <Properties> <displayName>NCK1 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="100" reactomeId="9835328" points="673 1087, 673 1089, 778 1089" position="673 1089" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="536 978, 601 1067" /> <Input id="101" points="651 1098" /> </Inputs> <Outputs> <Output id="99" /> </Outputs> <Properties> <displayName>NPM binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="116" reactomeId="9835358" points="690 1169, 690 1169, 758 1169" position="690 1169" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="533 978, 593 1139" /> <Input id="117" points="671 1177" /> </Inputs> <Outputs> <Output id="114" /> </Outputs> <Properties> <displayName>p-TARBP2 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="119" reactomeId="9835385" points="678 1237, 678 1237, 777 1237" position="678 1237" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="531 978, 579 1206" /> <Input id="120" points="645 1250" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> <Properties> <displayName>DUS2 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="122" reactomeId="9835411" points="698 1326, 703 1323, 770 1323" position="703 1323" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="123" points="685 1336" /> <Input id="4" points="530 978, 574 1275" /> </Inputs> <Outputs> <Output id="121" /> </Outputs> <Properties> <displayName>FA core complex:HSP70s binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="125" reactomeId="9835443" points="720 1423, 717 1423, 719 1423, 767 1422" position="719 1423" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="443" points="683 1422" /> <Input id="4" points="530 978, 578 1367" /> </Inputs> <Outputs> <Output id="124" /> </Outputs> <Properties> <displayName>STAT1,STAT3 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="9835454" points="708 1488, 707 1487, 773 1488" position="707 1487" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="136" points="659 1508" /> <Input id="4" points="529 978, 560 1465" /> </Inputs> <Outputs> <Output id="134" /> </Outputs> <Properties> <displayName>DNAJC3 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="314" reactomeId="9835992" points="727 1794, 725 1794, 763 1796" position="725 1794" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="545" points="686 1794" /> <Input id="4" points="529 978, 532 1738" /> </Inputs> <Outputs> <Output id="544" /> </Outputs> <Properties> <displayName>VTRNA2-1 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="316" reactomeId="9835949" points="701 1651, 697 1654, 779 1652" position="697 1654" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="317" points="647 1651" /> <Input id="4" points="529 978, 539 1599" /> </Inputs> <Outputs> <Output id="143" /> </Outputs> <Properties> <displayName>HIV Tat72 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="319" reactomeId="168896" points="692 1574, 695 1573, 759 1575" position="695 1573" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="4" points="529 978, 551 1540" /> <Input id="320" points="663 1580" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> <Properties> <displayName>NS1 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="322" reactomeId="9833436" points="721 1863, 722 1863, 789 1864" position="722 1863" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="323" points="685 1862" /> <Input id="4" points="528 978, 522 1783" /> </Inputs> <Outputs> <Output id="305" /> </Outputs> <Properties> <displayName>RSV N binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="325" reactomeId="9835940" points="1568 1089, 1569 1090, 1570 1136" position="1569 1090" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="29" points="1660 976" /> <Input id="313" points="1489 1074" /> </Inputs> <Outputs> <Output id="326" /> </Outputs> <Properties> <displayName>HCMV TRS1 binds PKR dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="327" reactomeId="9835944" points="702 1935, 701 1936, 757 1932" position="701 1936" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="528 978, 508 1861" /> <Input id="328" points="656 1934" /> </Inputs> <Outputs> <Output id="162" /> </Outputs> <Properties> <displayName>ADAR1 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="329" reactomeId="9835885" points="1667 1363, 1668 1362, 1669 1365" position="1668 1362" lineWidth="1.0"> <Inputs> <Input id="330" points="1628 1333" /> <Input id="331" points="1626 1364" /> </Inputs> <Outputs> <Output id="332" points="1702 1335" /> <Output id="333" points="1712 1364" /> </Outputs> <Catalysts> <Catalyst id="29" points="1669 976" /> </Catalysts> <Inhibitors> <Inhibitor id="313" points="1461 1086, 1467 1423, 1602 1425" /> <Inhibitor id="323" points="685 1871, 814 1892, 1379 1887, 1609 1437" /> </Inhibitors> <Properties> <displayName>p-PKR dimer phosphorylates eIF2-alpha</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="334" reactomeId="9836159" points="1319 660, 1331 661, 1346 660" position="1331 661" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="335" points="1305 660" /> <Input id="436" points="1290 618" /> </Inputs> <Outputs> <Output id="336" points="1365 660" /> <Output id="437" points="1379 617" /> </Outputs> <Catalysts> <Catalyst id="29" points="1663 947, 1615 866" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates DHX9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="342" reactomeId="9836184" points="1499 565, 1501 565, 1503 565" position="1501 565" lineWidth="1.0"> <Inputs> <Input id="343" points="1471 566" /> <Input id="344" points="1455 523" /> </Inputs> <Outputs> <Output id="345" points="1532 566" /> <Output id="346" points="1538 519" /> </Outputs> <Catalysts> <Catalyst id="29" points="1665 947" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates CDK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="347" reactomeId="9836322" points="1776 589, 1776 589, 1778 589" position="1776 589" lineWidth="1.0"> <Inputs> <Input id="348" stoichiometry="2" points="1726 545" /> <Input id="349" points="1728 590" /> </Inputs> <Outputs> <Output id="350" points="1839 589" /> <Output id="351" stoichiometry="2" points="1808 548" /> </Outputs> <Catalysts> <Catalyst id="29" points="1673 947" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates MKK6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="375" reactomeId="9836362" points="1822 1679, 1822 1680, 1831 1679" position="1822 1680" lineWidth="1.0"> <Inputs> <Input id="376" stoichiometry="4" points="1790 1722" /> <Input id="377" points="1775 1679" /> </Inputs> <Outputs> <Output id="379" points="1889 1679" /> <Output id="536" stoichiometry="4" points="1872 1722" /> </Outputs> <Catalysts> <Catalyst id="354" points="1818 1622" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates TP53 tetramer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="380" reactomeId="9836383" points="2041 557, 2040 558, 2042 564" position="2040 558" lineWidth="1.0"> <Inputs> <Input id="381" stoichiometry="2" points="2119 534" /> <Input id="382" points="2041 509" /> </Inputs> <Outputs> <Output id="383" points="2042 609" /> <Output id="384" stoichiometry="2" points="2119 594" /> <Output id="385" points="2124 638" /> </Outputs> <Catalysts> <Catalyst id="29" points="1680 947" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates ILF3:ILF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="395" reactomeId="9836404" points="2006 764, 2004 764, 2009 764" position="2004 764" lineWidth="1.0"> <Inputs> <Input id="396" stoichiometry="8" points="2074 729" /> <Input id="397" points="2005 726" /> </Inputs> <Outputs> <Output id="398" points="2006 800" /> <Output id="399" stoichiometry="8" points="2107 781" /> <Output id="400" points="2154 830" /> </Outputs> <Catalysts> <Catalyst id="29" points="1689 947" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates MAPT</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="401" reactomeId="9836435" points="2293 889, 2292 890, 2293 890" position="2292 890" lineWidth="1.0"> <Inputs> <Input id="402" points="2293 846" /> <Input id="403" points="2354 856" /> </Inputs> <Outputs> <Output id="404" points="2293 926" /> <Output id="405" points="2358 924" /> </Outputs> <Catalysts> <Catalyst id="29" points="1729 954" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates SNCA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="418" reactomeId="9836449" points="2077 1085, 2078 1087, 2077 1089" position="2078 1087" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="419" points="2077 1045" /> <Input id="420" stoichiometry="5" points="2150 1050" /> </Inputs> <Outputs> <Output id="421" stoichiometry="5" points="2169 1107" /> <Output id="422" points="2079 1123" /> </Outputs> <Catalysts> <Catalyst id="29" points="1707 976" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates HIV tat</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="423" reactomeId="9836500" points="1020 210, 1022 212, 1100 210" position="1022 212" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="424" points="975 251" /> <Input id="4" points="528 949, 489 213" /> </Inputs> <Outputs> <Output id="425" /> </Outputs> <Properties> <displayName>IKK complex is activated by PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="430" reactomeId="9836515" points="2017 1401, 2023 1400, 2031 1400" position="2023 1400" lineWidth="1.0"> <Inputs> <Input id="431" points="1985 1401" /> <Input id="432" points="1985 1429" /> </Inputs> <Outputs> <Output id="433" points="2076 1401" /> <Output id="434" points="2067 1429" /> </Outputs> <Catalysts> <Catalyst id="29" points="1678 976, 1918 1293" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates PTPN2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="445" reactomeId="9836606" points="698 1997, 706 1996, 771 1992" position="706 1996" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4" points="528 978, 494 1929" /> <Input id="446" points="660 2000" /> </Inputs> <Outputs> <Output id="444" /> </Outputs> <Properties> <displayName>SPHK1 binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="454" reactomeId="9836617" points="2101 1680, 2111 1682, 2118 1680" position="2111 1682" lineWidth="1.0"> <Inputs> <Input id="455" points="2072 1717" /> <Input id="456" points="2072 1680" /> </Inputs> <Outputs> <Output id="457" points="2153 1680" /> <Output id="458" points="2143 1717" /> </Outputs> <Catalysts> <Catalyst id="354" points="1874 1609, 2109 1646" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates SPHK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="463" reactomeId="9836621" points="2186 1700, 2188 1799, 1649 1799, 1373 2022, 753 2032, 660 2012" position="1649 1799" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="457" /> </Inputs> <Outputs> <Output id="446" /> </Outputs> <Properties> <displayName>p-S225-SPHK1 localizes to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="464" reactomeId="9836664" points="2094 1261, 2095 1268, 2094 1276" position="2095 1268" lineWidth="1.0"> <Inputs> <Input id="465" points="2094 1224" /> <Input id="466" points="2162 1242" /> </Inputs> <Outputs> <Output id="467" points="2097 1300" /> <Output id="468" points="2171 1292" /> </Outputs> <Catalysts> <Catalyst id="29" points="1683 976, 2039 1268" /> </Catalysts> <Properties> <displayName>p-PKR dimer phosphorylates PPP2R5A</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="486" reactomeId="9836702" points="697 2069, 708 2070, 759 2069" position="708 2070" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="487" points="664 2069" /> <Input id="4" points="528 978, 481 1994" /> </Inputs> <Outputs> <Output id="485" /> </Outputs> <Properties> <displayName>PKR inhibitors bind PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="489" interactionType="Activate" points="414 966, 474 964" position="444 965" lineWidth="2.0"> <Inputs> <Input id="488" /> </Inputs> <Outputs> <Output id="4" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="493" interactionType="Activate" points="418 819, 575 820" position="496 819" lineWidth="2.0"> <Inputs> <Input id="492" /> </Inputs> <Outputs> <Output id="42" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="496" interactionType="Activate" points="418 2017, 569 2006" position="493 2011" lineWidth="2.0"> <Inputs> <Input id="495" /> </Inputs> <Outputs> <Output id="446" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="500" interactionType="Activate" points="434 1546, 604 1525" position="519 1535" lineWidth="2.0"> <Inputs> <Input id="497" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="501" interactionType="Activate" points="434 1562, 589 1583" position="511 1572" lineWidth="2.0"> <Inputs> <Input id="497" /> </Inputs> <Outputs> <Output id="320" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="502" interactionType="Activate" points="426 495, 594 465" position="510 480" lineWidth="2.0"> <Inputs> <Input id="494" /> </Inputs> <Outputs> <Output id="82" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="506" interactionType="Activate" points="433 1650, 598 1650" position="515 1650" lineWidth="2.0"> <Inputs> <Input id="503" /> </Inputs> <Outputs> <Output id="317" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="509" interactionType="Activate" points="1447 1443, 1444 1108, 1455 1086" position="1444 1108" lineWidth="2.0"> <Inputs> <Input id="508" /> </Inputs> <Outputs> <Output id="313" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="511" interactionType="Activate" points="416 1870, 560 1864" position="488 1867" lineWidth="2.0"> <Inputs> <Input id="510" /> </Inputs> <Outputs> <Output id="323" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="515" interactionType="Activate" points="1584 1381, 1684 1420" position="1634 1400" lineWidth="2.0"> <Inputs> <Input id="331" /> </Inputs> <Outputs> <Output id="512" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="517" interactionType="Activate" points="1216 556, 1268 645" position="1242 600" lineWidth="2.0"> <Inputs> <Input id="516" /> </Inputs> <Outputs> <Output id="335" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="519" interactionType="Activate" points="1876 563, 1920 420" position="1898 491" lineWidth="2.0"> <Inputs> <Input id="350" /> </Inputs> <Outputs> <Output id="518" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="523" interactionType="Activate" points="2300 785, 2295 813" position="2297 799" lineWidth="2.0"> <Inputs> <Input id="522" /> </Inputs> <Outputs> <Output id="402" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="526" interactionType="Activate" points="2077 1002, 2077 1016" position="2077 1009" lineWidth="2.0"> <Inputs> <Input id="525" /> </Inputs> <Outputs> <Output id="419" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="538" reactomeId="9839016" points="825 291, 823 292, 950 341" position="823 292" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="4" stoichiometry="2" points="528 949, 511 292" /> <Input id="539" points="784 310" /> </Inputs> <Outputs> <Output id="540" /> </Outputs> <Activators> <Activator id="543" points="859 336" /> </Activators> <Properties> <displayName>PKR binds viral dsRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="546" reactomeId="9839025" points="693 1717, 713 1717, 761 1718" position="713 1717" lineWidth="1.0" isForDisease="true" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="553" points="658 1717" /> <Input id="4" points="529 978, 536 1664" /> </Inputs> <Outputs> <Output id="548" /> </Outputs> <Properties> <displayName>HIV TAR RNA binds PKR</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="554" interactionType="Activate" points="433 1669, 571 1707" position="502 1688" lineWidth="2.0"> <Inputs> <Input id="503" /> </Inputs> <Outputs> <Output id="553" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of PKR-mediated signaling (9833645)
