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Details on Person p-PKR dimer localizes to the nucleus

Class:Id	BlackBoxEvent:9833635
_displayName	p-PKR dimer localizes to the nucleus
_doRelease	TRUE
_timestamp	2025-01-29 09:16:46
authored	[InstanceEdit:9833574] Stephan, Ralf, 2023-05-01
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9833621] Stephan, Ralf, 2023-05-02
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
input	[Complex:9833821] p-EIF2AK2 dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9833553] Functional characterization of and cooperation between the double-stranded RNA-binding motifs of the protein kinase PKR [LiteratureReference:9833640] Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts [LiteratureReference:9833624] Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells [LiteratureReference:9833620] Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells [LiteratureReference:9833625] Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells [LiteratureReference:9836556] Cell fate determined by the activation balance between PKR and SPHK1 [LiteratureReference:9842000] Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division [LiteratureReference:9841998] Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress
modified	[InstanceEdit:9836330] Stephan, Ralf, 2023-05-26 [InstanceEdit:9836352] Stephan, Ralf, 2023-05-26 [InstanceEdit:9836551] Stephan, Ralf, 2023-05-30 [InstanceEdit:9841795] Matthews, Lisa, 2023-08-14 [InstanceEdit:9841952] Stephan, Ralf, 2023-08-16 [InstanceEdit:9841997] Stephan, Ralf, 2023-08-16 [InstanceEdit:9937069] Stephan, Ralf, 2025-01-29
name	p-PKR dimer localizes to the nucleus
output	[Complex:9836331] p-EIF2AK2 dimer [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1015702] Expression of IFN-induced genes [Homo sapiens] [Reaction:1015699] ISGF3 binds the ISRE promoter elements in IFN-stimulated genes [Homo sapiens]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9833643] R-HSA-9833635.2
summation	[Summation:9833631] PKR (EIF2AK2) is primarily localized in the cytoplasm. The s...
(hasEvent)	[Pathway:9833482] PKR-mediated signaling [Homo sapiens]
(precedingEvent)	[Reaction:9836617] p-PKR dimer phosphorylates SPHK1 [Homo sapiens]
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No pathways have been reviewed or authored by p-PKR dimer localizes to the nucleus (9833635)