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Details on Person Expression of Gbx2 in the posterior neural plate is strongly...

Class:IdSummation:9833304
_displayNameExpression of Gbx2 in the posterior neural plate is strongly...
_timestamp2023-07-12 02:01:13
created[InstanceEdit:9833287] May, Bruce, 2023-04-19
literatureReference[LiteratureReference:9832925] Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate
[LiteratureReference:9833291] Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
[LiteratureReference:9833298] Neural plate patterning: upstream and downstream of the isthmic organizer
[LiteratureReference:9839939] Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression
modified[InstanceEdit:9839942] May, Bruce, 2023-07-12
textExpression of Gbx2 in the posterior neural plate is strongly enhanced by Sox2, though it is unclear if Sox2 directly binds the Gbx2 gene (Iwafuchi-Doi et al. 2012, reviewed in Kondoh et al. 2016). Otx2 produced in the anterior neural plate is able to repress expression of Gbx2 even in the presence of Sox2 (Iwafuchi-Doi et al. 2012). The mutual antagonism of Gbx2 and Otx2 is believed to regulate midbrain and hindbrain patterning (Wassarman et al. 1997, Li and Joyner 2001, Martinez-Barbera et al. 2001, Wurst and Bally 2001).
(summation)[BlackBoxEvent:9833045] Expression of Gbx2 in posterior neural plate [Mus musculus]
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