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Details on Person 5' capping of respiratory syncytial virus (RSV) mRNAs is cat...
| Class:Id | Summation:9833095 |
|---|---|
| _displayName | 5' capping of respiratory syncytial virus (RSV) mRNAs is cat... |
| _timestamp | 2023-07-10 08:38:01 |
| created | [InstanceEdit:9833096] Orlic-Milacic, Marija, 2023-04-13 |
| modified | [InstanceEdit:9833101] Orlic-Milacic, Marija, 2023-04-13 [InstanceEdit:9833124] Orlic-Milacic, Marija, 2023-04-13 [InstanceEdit:9833148] Orlic-Milacic, Marija, 2023-04-13 [InstanceEdit:9833242] Orlic-Milacic, Marija, 2023-04-14 [InstanceEdit:9834776] Orlic-Milacic, Marija, 2023-05-10 [InstanceEdit:9834873] Orlic-Milacic, Marija, 2023-05-10 [InstanceEdit:9838131] Orlic-Milacic, Marija, 2023-06-21 [InstanceEdit:9838750] Orlic-Milacic, Marija, 2023-06-26 [InstanceEdit:9839741] Stephan, Ralf, 2023-07-10 |
| text | 5' capping of respiratory syncytial virus (RSV) mRNAs is catalyzed by the polyribonucleotidyl transferase and methyltransferase domains of the catalytic subunit L of the RNA-dependent RNA polymerase (RdRP) complex. The capping of RSV mRNAs is a two-step process, involving cap0 and then cap1 creation. The so-called cap0, labeled m7GpppG- as all RSV transcripts start with guanidine (Liuzzi et al. 2005), is created through N7 methylation catalyzed by the methyltransferase domain of the L protein. The complex of L and P proteins is sufficient for the N7-methylation to occur. In RSV, N7-methylation (cap0 creation) precedes 2'-O-methylation (cap1 creation) (Sutto-Ortiz et al. 2021). 5' capping was confirmed in: 1C (NS1) mRNA (Collins and Wertz 1985; Liuzzi et al. 2005), 1B (NS2) mRNA (Collins and Wertz 1985; Liuzzi et al. 2005), N mRNA (Liuzzi et al. 2005), P mRNA (Liuzzi et al. 2005), M mRNA (Satake and Venkatesan 1984; Liuzzi et al. 2005), SH mRNA (Liuzzi et al. 2005), G mRNA (Liuzzi et al. 2005), F mRNA (Elango et al. 1985; Liuzzi et al. 2005), M2 mRNA (Liuzzi et al. 2005), and L mRNA (Liuzzi et al. 2005). |
| (summation) | [BlackBoxEvent:9830848] L protein acts as a cap N7 methyltransferase to modify RSV mRNAs [Homo sapiens] |
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No pathways have been reviewed or authored by 5' capping of respiratory syncytial virus (RSV) mRNAs is cat... (9833095)
