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Details on Person Prior to gastrulation, Sox2 is expressed throughout the epib...
| Class:Id | Summation:9833011 |
|---|---|
| _displayName | Prior to gastrulation, Sox2 is expressed throughout the epib... |
| _timestamp | 2023-07-12 01:14:17 |
| created | [InstanceEdit:9832992] May, Bruce, 2023-04-11 |
| literatureReference | [LiteratureReference:9833216] SoxB transcription factors specify neuroectodermal lineage choice in ES cells [LiteratureReference:9832819] Intrinsic regulations in neural fate commitment [LiteratureReference:9832996] Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1 |
| modified | [InstanceEdit:9833226] May, Bruce, 2023-04-13 [InstanceEdit:9837396] May, Bruce, 2023-06-14 [InstanceEdit:9839941] May, Bruce, 2023-07-12 |
| text | Prior to gastrulation, Sox2 is expressed throughout the epiblast (Wood and Episkopou 1999). During gastrulation Sox2 becomes restricted to the presumptive neuroectoderm in the anterior ectoderm and persists in the neural plate and neural tube (Wood and Episkopou 1999, Avilion et al. 2003, Uchikawa et al. 2011, Iwafuchi-Doi et al. 2012). Sox2 is considered to be the earliest marker of developing neurectoderm (Tang et al. 2015). In the anterior neural plate, first Pou5f1, then Pou3f1 bind the N2 enhancer upstream of the Sox2 coding region and activate transcription of Sox2 (Iwafuchi Doi et al. 2011, Zhu et al. 2014). In posterior neural plate, Wnt signaling and Fgf signaling act on the N1 enhancer downstream of the Sox2 coding region (Takemoto et al. 2006). Forced expression of Sox2 is able to direct embryonic stem cells to differentiate into neuroectoderm (Zhao et al. 2004). |
| (summation) | [BlackBoxEvent:9832812] Expression of Sox2 in anterior neural plate [Mus musculus] |
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