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Details on Person Expression of Otx2 in anterior neural plate

Class:Id	BlackBoxEvent:9832924
_displayName	Expression of Otx2 in anterior neural plate
_doRelease	TRUE
_timestamp	2023-07-12 16:50:57
authored	[InstanceEdit:9832921] May, Bruce, 2023-04-10
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9832945] May, Bruce, 2023-04-10
edited	[InstanceEdit:9832921] May, Bruce, 2023-04-10
input	[EntityWithAccessionedSequence:9832941] Otx2 gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9837437] Matthews, Lisa, 2023-06-14
isChimeric	FALSE
literatureReference	[LiteratureReference:9832825] The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways [LiteratureReference:9832826] Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells [LiteratureReference:9833077] Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors
modified	[InstanceEdit:9833093] May, Bruce, 2023-04-13 [InstanceEdit:9833277] May, Bruce, 2023-04-18 [InstanceEdit:9837438] May, Bruce, 2023-06-14 [InstanceEdit:9839946] May, Bruce, 2023-07-12
name	Expression of Otx2 in anterior neural plate
output	[EntityWithAccessionedSequence:9832933] Otx2 [nucleoplasm] [Mus musculus]
regulatedBy	[PositiveGeneExpressionRegulation:9832923] Positive gene expression regulation by 'Pou3f1:Otx2 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9833042] Negative gene expression regulation by 'Gbx2:Otx2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9832946] Positive gene expression regulation by 'Pou3f1:Otx2 gene [nucleoplasm]' The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways [RegulationReference:9833053] Negative gene expression regulation by 'Gbx2:Otx2 gene [nucleoplasm]' A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
releaseDate	2023-09-13
reviewed	[InstanceEdit:9839944] Kondoh, Hisato, 2023-07-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9832968] R-MMU-9832924.1
structureModified	[InstanceEdit:9833093] May, Bruce, 2023-04-13
summation	[Summation:9833264] Otx2 is expressed specifically in the anterior neural plate ...
(inferredFrom)	[BlackBoxEvent:9832938] Expression of OTX2 in anterior neural plate [Homo sapiens]
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No pathways have been reviewed or authored by Expression of Otx2 in anterior neural plate (9832924)