Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Kinesins consume ATP to power the motor which allows them to...
| Class:Id | Summation:983258 |
|---|---|
| _displayName | Kinesins consume ATP to power the motor which allows them to... |
| _timestamp | 2010-11-15 18:03:05 |
| created | [InstanceEdit:983242] Jupe, S, 2010-10-29 |
| literatureReference | [LiteratureReference:983180] A structural change in the kinesin motor protein that drives motility [LiteratureReference:990508] Structural mechanism of muscle contraction [LiteratureReference:1015862] An atomic-level mechanism for activation of the kinesin molecular motors [LiteratureReference:990512] ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism |
| modified | [InstanceEdit:990475] Jupe, S, 2010-11-03 [InstanceEdit:1015865] Jupe, S, 2010-11-15 |
| text | Kinesins consume ATP to power the motor which allows them to move along microtubules. The motor region contains highly conserved Switch 1 (SSRSH) and 2 (DLAGSE) motifs which change conformation during ATP hydrolysis (Rice et al. 1999). These form a salt-bridge that, in myosin, closes the nucleotide-binding cleft, enabling the motor to hydrolyze ATP (Geeves & Holmes 1999). This closed conformation has now been seen by cryo-electron microscopy in human conventional kinesin (Sindelar & Downing 2010) and in a crystal structure of the frog kinesin-5 Eg5 (Parke et al. 2010). |
| (summation) | [BlackBoxEvent:983259] Kinesins move along microtubules consuming ATP [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Kinesins consume ATP to power the motor which allows them to... (983258)
