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Details on Person Sine oculis homolog 2 (SIX2) is expressed in metanephric mes...

Class:IdSummation:9831805
_displayNameSine oculis homolog 2 (SIX2) is expressed in metanephric mes...
_timestamp2023-04-20 15:21:08
created[InstanceEdit:9831812] May, Bruce, 2023-03-25
literatureReference[LiteratureReference:9831787] Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
[LiteratureReference:9831789] Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
[LiteratureReference:9831809] Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks
[LiteratureReference:9831804] Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators
modified[InstanceEdit:9831849] May, Bruce, 2023-03-25
[InstanceEdit:9832759] May, Bruce, 2023-04-06
[InstanceEdit:9833343] May, Bruce, 2023-04-20
textSine oculis homolog 2 (SIX2) is expressed in metanephric mesenchyme during formation of the metanephros, the adult kidney (O'Brien et al. 2016, and inferred from mouse homologs). Expression continues into development of nephrons where it is regulated by either SIX1 or SIX2 (O'Brien et al. 2016). In mouse embryos, Six2 appears to maintain metanephric mesenchyme in a less differentiated, more proliferative state (Self et al. 2006, Kobayashi et al. 2008, Park et al. 2012).
(summation)[BlackBoxEvent:9831006] Expression of SIX2 in metanephric mesenchyme [Homo sapiens]
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