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Details on Person The Eyes absent homolog1 (Eya1) is expressed and specifies m...

Class:IdSummation:9831751
_displayNameThe Eyes absent homolog1 (Eya1) is expressed and specifies m...
_timestamp2023-04-06 00:57:35
created[InstanceEdit:9831756] May, Bruce, 2023-03-24
literatureReference[LiteratureReference:9831761] Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia
modified[InstanceEdit:9831825] May, Bruce, 2023-03-25
[InstanceEdit:9832759] May, Bruce, 2023-04-06
textThe Eyes absent homolog1 (Eya1) is expressed and specifies metanephric mesenchyme (also called blastema) (Kalatzis et al. 1998, Sajithlal et al. 2005). Odd skipped related 1 (Osr1, also called Odd1) activates expression of Eya1 in the metanephric mesenchyme (James et al. 2006). Mice that are mutant for Osr1 do not express detectable Eya1, indicating an absolute requirement for Osr1 (James et al. 2006). The Osr1 mutants also have abnormalities of the nephric duct and mesonephros, and fail to form metanephric mesenchyme (James et al. 2006). Mice lacking Eya1 fail to form kidneys (Xu et al. 1999).
(summation)[BlackBoxEvent:9830929] Expression of Eya1 in metanephric mesenchyme [Mus musculus]
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