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Details on Person Trimming of peptides in ER

Class:Id	BlackBoxEvent:983158
_displayName	Trimming of peptides in ER
_doRelease	TRUE
_timestamp	2016-10-28 16:23:44
authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983143] endopeptidase activity of ERAP1/2 [endoplasmic reticulum lumen]
catalystActivityReference	[CatalystActivityReference:9643201] endopeptidase activity of ERAP1/2 [endoplasmic reticulum lumen] The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
input	[SimpleEntity:983034] oligopeptide fragment [endoplasmic reticulum lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:982896] An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides [LiteratureReference:982961] The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues [LiteratureReference:985505] ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum
modified	[InstanceEdit:983423] Garapati, P V, 2010-11-01 [InstanceEdit:985506] Garapati, P V, 2010-11-03 [InstanceEdit:1004533] Garapati, P V, 2010-11-09 [InstanceEdit:1027409] Garapati, P V, 2010-11-18 [InstanceEdit:1093901] Matthews, L, 2010-11-29 [InstanceEdit:1213483] Garapati, P V, 2011-02-11 [InstanceEdit:1222763] Garapati, P V, 2011-02-28 [InstanceEdit:1295503] Garapati, P V, 2011-05-16 [InstanceEdit:8943717] D'Eustachio, Peter, 2016-10-28 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Trimming of peptides in ER
output	[SimpleEntity:983033] Antigen peptide [endoplasmic reticulum lumen] [SimpleEntity:8943716] L-amino acid [endoplasmic reticulum lumen]
precedingEvent	[Reaction:983144] Transport of Antigen peptide in to ER [Homo sapiens] [BlackBoxEvent:983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases [Homo sapiens] [BlackBoxEvent:983150] Proteasomal cleavage of substrate [Homo sapiens] [BlackBoxEvent:9912636] Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst) [Homo sapiens] [BlackBoxEvent:9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) [Homo sapiens] [BlackBoxEvent:9912747] Proteasomal clevage of exogenous antigen (immunoproteasome catalyst) [Homo sapiens]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357530] R-HSA-983158.4
summation	[Summation:982842] Transporter associated with antigen processing (TAP) prefers...
(hasEvent)	[Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC [Homo sapiens]
(precedingEvent)	[Reaction:8951499] Loading of antigenic peptides on to class I MHC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782560] Update Tracker - [BlackBoxEvent:983158] Trimming of peptides in ER - v59:[add_removeOutput]
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