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Details on Person E1 mediated ubiquitin activation

Class:Id	Reaction:983153
_displayName	E1 mediated ubiquitin activation
_doRelease	TRUE
_timestamp	2011-06-10 08:41:47
authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983141] ubiquitin-protein transferase activity of Ubiquitin activating E1 enzymes [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
input	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [CandidateSet:947695] Ubiquitin activating E1 enzymes [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29926] Mg2+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:976179] Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme [LiteratureReference:976173] Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes [LiteratureReference:976168] Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
modified	[InstanceEdit:1004532] Garapati, P V, 2010-11-09 [InstanceEdit:1027408] Garapati, P V, 2010-11-18 [InstanceEdit:1093901] Matthews, L, 2010-11-29 [InstanceEdit:1213481] Garapati, P V, 2011-02-11 [InstanceEdit:1222763] Garapati, P V, 2011-02-28 [InstanceEdit:1295503] Garapati, P V, 2011-05-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	E1 mediated ubiquitin activation
output	[Complex:976164] E1 bound ubiquitin [cytosol] [Homo sapiens] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:29926] Mg2+ [cytosol]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357514] R-HSA-983153.2
summation	[Summation:976169] Ubiquitin is activated in an ATP-dependent manner, catalyzed...
(hasEvent)	[Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation [Homo sapiens]
(precedingEvent)	[Reaction:983152] Transfer of ubiquitin from E1 to E2 [Homo sapiens]
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No pathways have been reviewed or authored by E1 mediated ubiquitin activation (983153)