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Details on Person Expression of Gdnf in metanephric mesenchyme

Class:Id	BlackBoxEvent:9830744
_displayName	Expression of Gdnf in metanephric mesenchyme
_doRelease	TRUE
_timestamp	2023-10-31 01:10:00
authored	[InstanceEdit:9830701] May, Bruce, 2023-03-13
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:9830747] May, Bruce, 2023-03-14
edited	[InstanceEdit:9830701] May, Bruce, 2023-03-13
input	[EntityWithAccessionedSequence:9830963] Gdnf gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9835794] Matthews, Lisa, 2023-05-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9830952] A Hox-Eya-Pax complex regulates early kidney developmental gene expression [LiteratureReference:9830738] Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development [LiteratureReference:9830956] Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney [LiteratureReference:9831043] SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site [LiteratureReference:9831042] ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation [LiteratureReference:9831799] Hox11 paralogous genes are essential for metanephric kidney induction [LiteratureReference:8871563] Defects in enteric innervation and kidney development in mice lacking GDNF [LiteratureReference:9831841] Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium [LiteratureReference:9831885] Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions [LiteratureReference:9830968] The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression
modified	[InstanceEdit:9831002] May, Bruce, 2023-03-17 [InstanceEdit:9831081] May, Bruce, 2023-03-17 [InstanceEdit:9831814] May, Bruce, 2023-03-25 [InstanceEdit:9831849] May, Bruce, 2023-03-25 [InstanceEdit:9831900] May, Bruce, 2023-03-26 [InstanceEdit:9832755] May, Bruce, 2023-04-05 [InstanceEdit:9851767] May, Bruce, 2023-10-31
name	Expression of Gdnf in metanephric mesenchyme
output	[EntityWithAccessionedSequence:9830758] Gdnf [extracellular region] [Mus musculus]
regulatedBy	[PositiveGeneExpressionRegulation:9830755] Positive gene expression regulation by 'N4GlycoAsn-PalmS Wnt11 [extracellular region]' [PositiveGeneExpressionRegulation:9830940] Positive gene expression regulation by 'Npnt:Itga8:Itgb1 [plasma membrane]' [PositiveGeneExpressionRegulation:9830927] Positive gene expression regulation by 'Eya1:Pax2:Hox11 paralog:Gdnf gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9792540] Negative gene expression regulation by 'Foxc1 [nucleoplasm]' [NegativeGeneExpressionRegulation:9792549] Negative gene expression regulation by 'Foxc2 [nucleoplasm]' [NegativeGeneExpressionRegulation:9831040] Negative gene expression regulation by 'Robo2:Slit2 [plasma membrane]'
regulationReference	[RegulationReference:9830746] Positive gene expression regulation by 'N4GlycoAsn-PalmS Wnt11 [extracellular region]' Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development [RegulationReference:9830958] Positive gene expression regulation by 'Npnt:Itga8:Itgb1 [plasma membrane]' Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney [RegulationReference:9830922] Positive gene expression regulation by 'Eya1:Pax2:Hox11 paralog:Gdnf gene [nucleoplasm]' A Hox-Eya-Pax complex regulates early kidney developmental gene expression [RegulationReference:9831024] Negative gene expression regulation by 'Foxc1 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract [RegulationReference:9831032] Negative gene expression regulation by 'Foxc2 [nucleoplasm]' Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract [RegulationReference:9831010] Negative gene expression regulation by 'Robo2:Slit2 [plasma membrane]' SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9830776] R-MMU-9830744.1
structureModified	[InstanceEdit:9831002] May, Bruce, 2023-03-17 [InstanceEdit:9831081] May, Bruce, 2023-03-17
summation	[Summation:9831056] Glial cell line-derived neurotrophic factor (Gdnf) is expres...
(inferredFrom)	[BlackBoxEvent:9830765] Expression of GDNF in metanephric mesenchyme [Homo sapiens]
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