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Details on Person IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex

Class:Id	BlackBoxEvent:9830710
_displayName	IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex
_doRelease	TRUE
_timestamp	2024-03-01 02:46:21
authored	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9830704] Shamovsky, Veronica, 2023-03-13
edited	[InstanceEdit:9863258] Shamovsky, Veronica, 2024-02-28
input	[Complex:9828203] IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9832591] D'Eustachio, Peter, 2023-04-03 [InstanceEdit:9839724] Matthews, Lisa, 2023-07-10
isChimeric	FALSE
literatureReference	[LiteratureReference:433880] Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes [LiteratureReference:9705328] IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex
modified	[InstanceEdit:9830719] Shamovsky, Veronica, 2023-03-13 [InstanceEdit:9830721] Shamovsky, Veronica, 2023-03-13 [InstanceEdit:9832596] Shamovsky, Veronica, 2023-04-03 [InstanceEdit:9839318] Shamovsky, Veronica, 2023-07-05 [InstanceEdit:9839723] Shamovsky, Veronica, 2023-07-10 [InstanceEdit:9862120] Shamovsky, Veronica, 2024-02-23 [InstanceEdit:9863277] Shamovsky, Veronica, 2024-02-28 [InstanceEdit:9863514] Shamovsky, Veronica, 2024-03-01
name	IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex IKBKE is ubiquitinated within IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral
output	[Complex:9830703] K63pUb-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9828204] IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 [Homo sapiens] [BlackBoxEvent:9013990] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863280] Munitić, Ivana, Franjkić, Toni, 2024-02-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9830715] R-HSA-9830710.1
structureModified	[InstanceEdit:9830721] Shamovsky, Veronica, 2023-03-13
summation	[Summation:9839319] Pathogen-associated inflammatory signaling pathways result i...
(hasEvent)	[Pathway:9828211] Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation [Homo sapiens]
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