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Details on Person K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]

Class:Id	Complex:9830705
_displayName	K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane]
_timestamp	2023-03-13 22:18:35
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9830704] Shamovsky, Veronica, 2023-03-13
hasComponent	[Complex:9013976] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:5362480] K63polyUb-TANK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5362480] K63polyUb-TANK [cytosol] [Homo sapiens] [Complex:9013989] K63polyUb-TRAF3:TICAM1:activated TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:936402] K63polyUb-TRAF3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936402] K63polyUb-TRAF3 [cytosol] [Homo sapiens] [Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] [Homo sapiens] [Complex:167985] viral dsRNA :TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2000341] TLR3 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:2000341] TLR3 [endosome membrane] [Homo sapiens] [DefinedSet:9038432] TLR3 ligand [endosome lumen] [Hepatitis B virus] [EntityWithAccessionedSequence:450316] TICAM1 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:450316] TICAM1 [endosome membrane] [Homo sapiens] [Complex:9730427] K63polyUb-K30,K401-TBK1 homodimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9730430] K63polyUb-K30,K401-TBK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9730430] K63polyUb-K30,K401-TBK1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:2423829] Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling [LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
name	K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9830712] R-HSA-9830705.1
(output)	[BlackBoxEvent:9828200] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [Homo sapiens]
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No pathways have been reviewed or authored by K63polyUb-TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 [endosome membrane] (9830705)