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Details on Person UniProt:Q62077 Plcg1
| Class:Id | ReferenceGeneProduct:98301 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-1302 added on Fri February 6 2015;initiator methionine:1 for 98301 removed on Fri Nov 03 2023;initiator methionine: for 98301 added on Fri Nov 03 2023;initiator methionine: for 98301 removed on Fri Aug 15 2025;initiator methionine:1 for 98301 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q62077 Plcg1 |
| _timestamp | 2025-08-15 22:03:14 |
| chain | initiator methionine:1 chain:2-1302 |
| checksum | 5D123C508D425EB2 |
| comment | FUNCTION Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Plays a role in actin reorganization and cell migration (By similarity). Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis (By similarity).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)COFACTOR Activated by phosphorylation on tyrosine residues.SUBUNIT Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with RALGPS1. Interacts (via SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with RET (By similarity). Interacts with AGAP2 via its SH3 domain. Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK. Interacts with FLT4 and KIT. Interacts with AXL (By similarity). Interacts with SYK; activates PLCG1 (By similarity). Interacts with FLT1 (tyrosine-phosphorylated). Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C. Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with TESPA1 (By similarity). Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1. Interacts (via C-terminal proline-rich domain (PRD)) with PLCG1 (via SH3 domain); this interaction leads to guanine nucleotide exchange from PlCG1 to DNM1 and enhances DNM1-dependent endocytosis (By similarity).INTERACTION Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.DOMAIN The SH3 domain mediates interaction with RALGPS1 (By similarity). The SH3 domain also mediates interaction with CLNK.PTM Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells. May be dephosphorylated by PTPRJ (By similarity).PTM Ubiquitinated by CBLB in activated T-cells. |
| description | recommendedName: fullName evidence="27"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 ecNumber evidence="2"3.1.4.11 alternativeName: Phosphoinositide phospholipase C-gamma-1 alternativeName: Phospholipase C-gamma-1 shortName: PLC-gamma-1 |
| geneName | Plcg1 Plcg-1 |
| identifier | Q62077 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Calcium Cell projection Hydrolase Lipid degradation Lipid metabolism Metal-binding Phosphoprotein Reference proteome Repeat SH2 domain SH3 domain Transducer Ubl conjugation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Plcg1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PLCG1_MOUSE Q6P1G1 |
| sequenceLength | 1302 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1251925] Plcg1 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:1251936] P-Plcg1 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:9029083] p-Y-Plcg1 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:9030452] p-4Y-Plcg1 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:9638030] Plcg1 [cytosol] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:1251921] O4'-phospho-L-tyrosine at 472 [ModifiedResidue:1251928] O4'-phospho-L-tyrosine at 783 [ModifiedResidue:1251933] O4'-phospho-L-tyrosine at 1253 [ModifiedResidue:1251946] O4'-phospho-L-tyrosine at 771 [ModifiedResidue:9029093] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q62077 Plcg1 (98301)
