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Details on Person UniProt:P03423-1 G

Class:Id	ReferenceIsoform:9828692
_chainChangeLog	chain:1-298 for 9828692 added on Fri February 24 2023;chain:66-298 for 9828692 added on Fri February 24 2023
_displayName	UniProt:P03423-1 G
_timestamp	2024-11-03 20:05:30
chain	chain:1-298 chain:66-298
checksum	993C3D2DD68BC634
comment	FUNCTION Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection (PubMed:10400758, PubMed:10864656, PubMed:3655746). Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection (PubMed:11477410, PubMed:26107373, PubMed:26658574). Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities (Probable).FUNCTION Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.SUBUNIT Homooligomer (PubMed:1634876). Interacts (via N-terminus) with protein M (PubMed:15958665). Part of a complex composed of F1, F2 and G glycoproteins (PubMed:18036342). Interacts with protein SH (PubMed:15659757). Interacts with host heparate sulfate; this interaction probably participates in the viral attachment to the host cell (PubMed:10400758). Interacts with host CX3CR1; this interaction plays an important role in viral entry (PubMed:11477410, PubMed:26658574). Interacts with the host lectins CD209/DC-SIGN and CD209L/L-SIGN on dendritic cells; these interactions stimulate the phosphorylation of MAPK3/ERK1 and MAPK1/ERK2, which inhibits dendritic cell activation and could participate in the limited immunity against RSV reinfection (PubMed:22090124).SUBCELLULAR LOCATION The protein is shed from infected cells before the appearance of progeny virus (By similarity). The initiation at the downstream methionine removes a portion of the transmembrane domain. The remaining hydrophobic portion of the sG protein is essential for translocating it into the lumen of the ER during translation and would likely maintain its membrane association until a proteolytic event releases the mature sG protein into the medium (By similarity).ALTERNATIVE PRODUCTS Contains a linear heparin binding domain essential for virus attachment to the host.PTM Cleaved to give rise to the mature sG protein which lacks the transmembrane domain.PTM N- and O-glycosylated (PubMed:4069997). May carry 30-40 separate O-linked carbohydrate chains distributed among the 91 serine and threonine residues (PubMed:1634876, PubMed:2164608, PubMed:3858865).PTM Palmitoylated.SIMILARITY Belongs to the pneumoviruses glycoprotein G family.
created	[InstanceEdit:9828690] Orlic-Milacic, Marija, 2023-02-16
description	recommendedName: Major surface glycoprotein G alternativeName: Attachment glycoprotein G alternativeName: Membrane-bound glycoprotein shortName: mG component recommendedName: fullName evidence="1"Mature secreted glycoprotein G shortName evidence="1"Mature sG /component
geneName	G
identifier	P03423
isoformParent	[ReferenceGeneProduct:9828698] UniProt:P03423 G [Human respiratory syncytial virus A]
isSequenceChanged	FALSE
keyword	3D-structure Alternative initiation Direct protein sequencing Disulfide bond Glycoprotein Host cell membrane Host membrane Host-virus interaction Membrane Secreted Transmembrane Transmembrane helix Viral attachment to host adhesion receptor Viral attachment to host cell Viral immunoevasion Virion Virus entry into host cell
modified	[InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	G
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	GLYC_HRSVA Q77YB0
sequenceLength	298
species	[Species:9717528] Human respiratory syncytial virus A
variantIdentifier	P03423-1
(referenceEntity)	[EntityWithAccessionedSequence:9828696] Nascent G [endoplasmic reticulum membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9830861] Mature G [plasma membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9830865] G signal peptide [cytosol] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9830866] N-glycan-PALM-G [trans-Golgi network membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9830876] Mature G [trans-Golgi network membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9830879] N-glycan G [endoplasmic reticulum-Golgi intermediate compartment membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9830881] G [endoplasmic reticulum membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9835180] Mature G [virion membrane] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9837720] Mature G [macropinosome membrane] [Human respiratory syncytial virus A]
(referenceSequence)	[ModifiedResidue:9830859] N-glycosylated residue at unknown position [ModifiedResidue:9830863] N-palmitoyl-L-cysteine at unknown position [ModifiedResidue:9830877] O-glucosyl-L-serine at unknown position [ModifiedResidue:9830878] O-glycosyl-L-threonine at unknown position
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No pathways have been reviewed or authored by UniProt:P03423-1 G (9828692)