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Details on Person UniProt:P0DOE7 M

Class:Id	ReferenceGeneProduct:9828673
_chainChangeLog	chain:1-256 for 9828673 added on Fri February 24 2023
_displayName	UniProt:P0DOE7 M
_timestamp	2025-05-21 21:25:19
chain	chain:1-256
checksum	1E70706D65416BA0
comment	FUNCTION Plays a crucial role in virus assembly into filaments and budding (PubMed:23903836, PubMed:24672034, PubMed:25673702, PubMed:27654298). Early in infection, localizes in the nucleus where it inhibits host cell transcription through direct binding to host chromatin (PubMed:12827470, PubMed:34685766). Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication (PubMed:19297465, PubMed:23903836). During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer (PubMed:11907323, PubMed:12350355, PubMed:15958665, PubMed:18579594). Also plays a role in the inhibition of host interferon-beta response in a RACK1-dependent manner (PubMed:37712706).SUBUNIT Forms dimers (PubMed:25673702, PubMed:29510513). Forms higher-order oligomers (PubMed:24672034). Interacts with glycoprotein G (via N-terminus) (PubMed:15958665). Interacts with protein M2-1; this interaction directs the matrix protein localization to cytoplasmic inclusions comprising viral proteins L, N, P, and M2-1 and mediates the matrix protein association with the nucleocapsid (PubMed:18579594). Interacts with host importin KPNB1; this interaction mediates nuclear import of the matrix protein early during infection (PubMed:16171404). Interacts with host AP3M1; this interaction plays an essential role in trafficking the matrix protein in host cells (PubMed:29028839). Interacts with host CAV1; this interaction probably facilitates viral budding (PubMed:25556234). Interacts with host CFL1; this interaction probably facilitates viral replication (PubMed:25556234). Interacts with host ZNF502; this interaction probably facilitates viral release (PubMed:25556234). Interacts with host RACK1 (PubMed:37712706).INTERACTION In the cytoplasm, associates with inclusion bodies (PubMed:23903836). During bud formation, associates at the inner side of the plasma membrane of infected cells.PTM Phosphorylation is important for oligomerization.SIMILARITY Belongs to the pneumovirinae M protein family.
created	[InstanceEdit:9828671] Orlic-Milacic, Marija, 2023-02-16
description	recommendedName: Matrix protein alternativeName: fullName evidence="18"M protein
geneName	M
identifier	P0DOE7
isSequenceChanged	FALSE
keyword	3D-structure Host cell membrane Host cytoplasm Host membrane Host nucleus Host-virus interaction Membrane Phosphoprotein Viral matrix protein Virion
modified	[InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
name	M
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	MATRX_HRSVA P03419 Q77YB3
sequenceLength	256
species	[Species:9717528] Human respiratory syncytial virus A
(referenceEntity)	[EntityWithAccessionedSequence:9828672] Nascent M [cytosol] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9831678] p-S95,T205-M [cytosol] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9831706] p-S95,T205-M [nucleoplasm] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9831711] M [nucleoplasm] [Human respiratory syncytial virus A] [EntityWithAccessionedSequence:9836531] p-S95,T205-M [viral tegument] [Human respiratory syncytial virus A]
(referenceSequence)	[ModifiedResidue:9831689] O-phospho-L-serine at 95 [ModifiedResidue:9831707] O-phospho-L-threonine at 205
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No pathways have been reviewed or authored by UniProt:P0DOE7 M (9828673)