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Details on Person Formation of the NSL complex
Class:Id Reaction:9828175
_displayName Formation of the NSL complex
_doRelease TRUE
_timestamp 2023-02-13 14:50:53
authored [InstanceEdit:9823562] Orlic-Milacic, Marija, 2023-01-06
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:9828180] Orlic-Milacic, Marija, 2023-02-10
edited [InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13
input [EntityWithAccessionedSequence:1629838] WDR5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1629838] WDR5 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321875] KANSL1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321875] KANSL1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321796] KANSL2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321796] KANSL2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321882] KANSL3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321882] KANSL3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321849] MCRS1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321849] MCRS1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321845] OGT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321845] OGT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1592209] HCFC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1592209] HCFC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321802] KAT8 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3321802] KAT8 [nucleoplasm] [Homo sapiens] [DefinedSet:9828236] PHF20, PHF20L1 [nucleoplasm] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:3321809] A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16 [LiteratureReference:3321879] Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex [LiteratureReference:9828186] Methyl-lysine readers PHF20 and PHF20L1 define two distinct gene expression-regulating NSL complexes [LiteratureReference:9770965] Crosstalk between NSL histone acetyltransferase and MLL/SET complexes: NSL complex functions in promoting histone H3K4 di-methylation activity by MLL/SET complexes [LiteratureReference:9828167] Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis [LiteratureReference:9828177] PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation
modified [InstanceEdit:9828242] Orlic-Milacic, Marija, 2023-02-11 [InstanceEdit:9828330] Orlic-Milacic, Marija, 2023-02-13 [InstanceEdit:9828331] Orlic-Milacic, Marija, 2023-02-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Formation of the NSL complex
output [DefinedSet:9828237] NSL [nucleoplasm] [Homo sapiens]
releaseDate 2023-03-29
reviewed [InstanceEdit:9827909] Van, Hieu, 2023-02-08 [InstanceEdit:9827910] Ge, Kai, 2023-02-08
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:9828193] R-HSA-9828175.2
summation [Summation:9828172] WDR5 is a subunit of an evolutionarily conserved lysine acet...
(hasEvent) [Pathway:9772755] Formation of WDR5-containing histone-modifying complexes [Homo sapiens]
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