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Details on Person Expression of POU5F1 (OCT4) in primordial germ cells

Class:Id	BlackBoxEvent:9828023
_displayName	Expression of POU5F1 (OCT4) in primordial germ cells
_doRelease	TRUE
_timestamp	2023-05-09 02:19:42
authored	[InstanceEdit:9828007] May, Bruce, 2023-02-09
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9828025] May, Bruce, 2023-02-09
edited	[InstanceEdit:9828007] May, Bruce, 2023-02-09
input	[EntityWithAccessionedSequence:2888984] POU5F1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9827861] Sequential enhancer state remodelling defines human germline competence and specification [LiteratureReference:9828013] The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation [LiteratureReference:9828098] SOX17 is a critical specifier of human primordial germ cell fate [LiteratureReference:9828097] Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells [LiteratureReference:9828088] Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells [LiteratureReference:9828620] A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells
modified	[InstanceEdit:9828114] May, Bruce, 2023-02-10 [InstanceEdit:9828638] May, Bruce, 2023-02-16 [InstanceEdit:9833798] May, Bruce, 2023-05-03 [InstanceEdit:9834660] May, Bruce, 2023-05-09 [InstanceEdit:9835794] Matthews, Lisa, 2023-05-17
name	Expression of POU5F1 (OCT4) in primordial germ cells
output	[EntityWithAccessionedSequence:452472] POU5F1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9828032] SOX17 and TFAP2C bind the POU5F1 (OCT4) gene [Homo sapiens] [BlackBoxEvent:9827867] Expression of TFAP2C in primordial germ cells [Homo sapiens] [BlackBoxEvent:9828100] Expression of SOX17 in primordial germ cells [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9827996] Positive gene expression regulation by 'SOX17:TFAP2C:POU5F1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9828022] Positive gene expression regulation by 'SOX17:TFAP2C:POU5F1 gene [nucleoplasm]' Sequential enhancer state remodelling defines human germline competence and specification
releaseDate	2023-06-07
reviewed	[InstanceEdit:9833796] Tam, Patrick P L, 2023-05-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9828054] R-HSA-9828023.1
structureModified	[InstanceEdit:9828638] May, Bruce, 2023-02-16
summation	[Summation:9828617] The pluripotency factor POU5F1 (OCT4) (Nichols et al. 1998) ...
(hasEvent)	[Pathway:9827857] Specification of primordial germ cells [Homo sapiens]
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