Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The growth hormone receptor forms dimers (Cunningham et al. ...
| Class:Id | Summation:982800 |
|---|---|
| _displayName | The growth hormone receptor forms dimers (Cunningham et al. ... |
| _timestamp | 2011-06-23 14:55:24 |
| created | [InstanceEdit:982796] Jupe, S, 2010-10-28 |
| literatureReference | [LiteratureReference:982818] Disulfide bonds determine growth hormone receptor folding, dimerisation and ligand binding [LiteratureReference:982795] Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase [LiteratureReference:982797] Model for growth hormone receptor activation based on subunit rotation within a receptor dimer |
| modified | [InstanceEdit:1362469] Jupe, S, 2011-06-10 [InstanceEdit:1364048] Jupe, S, 2011-06-23 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 |
| text | The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005). Binding of growth hormone binding protein (GHBP) to growth hormone receptor (GHR) produces 'unproductive' dimers that prevent formation of signaling-capable GHR dimers (Ross et al. 1997). |
| (summation) | [Reaction:982775] Growth hormone receptor dimerizes [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The growth hormone receptor forms dimers (Cunningham et al. ... (982800)
