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Details on Person MITF-M-dependent PMEL gene expression
Class:Id BlackBoxEvent:9825846 _displayName MITF-M-dependent PMEL gene expression _doRelease TRUE _timestamp 2024-11-08 15:57:35 authored [InstanceEdit:9825798] Rothfels, Karen, 2023-01-26 compartment [Compartment:7660] nucleoplasm [Compartment:5668575] melanosome membrane created [InstanceEdit:9825866] Rothfels, Karen, 2023-01-27 edited [InstanceEdit:9825798] Rothfels, Karen, 2023-01-26 input [EntityWithAccessionedSequence:9825821] PMEL gene [nucleoplasm] [Homo sapiens] internalReviewed [InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17 isChimeric FALSE literatureReference [LiteratureReference:9855993] PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation [LiteratureReference:9855987] MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes [LiteratureReference:9855989] MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma [LiteratureReference:9855997] Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development [LiteratureReference:9855999] The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9730403] MITF-the first 25 years modified [InstanceEdit:9854922] Rothfels, Karen, 2023-11-28 [InstanceEdit:9856070] Rothfels, Karen, 2023-12-09 [InstanceEdit:9863248] Rothfels, Karen, 2024-02-28 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9927681] Rothfels, Karen, 2024-11-08 name MITF-M-dependent PMEL gene expression output [Complex:9856036] PMEL alpha:PMEL beta [melanosome membrane] [Homo sapiens] precedingEvent
previousReviewStatus [ReviewStatus:9821383] three stars regulatedBy [PositiveGeneExpressionRegulation:9825851] Positive gene expression regulation by 'MITF-M dimer:PMEL gene [nucleoplasm]' regulationReference [RegulationReference:9825861] Positive gene expression regulation by 'MITF-M dimer:PMEL gene [nucleoplasm]' MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma releaseDate 2024-03-27 reviewed [InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9825876] R-HSA-9825846.3 structureModified [InstanceEdit:9856070] Rothfels, Karen, 2023-12-09 summation [Summation:9856024] PMEL is a protein component of the melanosome that forms fib... (hasEvent) [Pathway:9824585] Regulation of MITF-M-dependent genes involved in pigmentation [Homo sapiens]
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