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Details on Person MITF-M-dependent TBX2 gene expression

Class:IdBlackBoxEvent:9825840
_displayNameMITF-M-dependent TBX2 gene expression
_doReleaseTRUE
_timestamp2024-11-08 15:57:48
authored[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9825866] Rothfels, Karen, 2023-01-27
edited[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input[EntityWithAccessionedSequence:9825817] TBX2 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimericFALSE
literatureReference[LiteratureReference:9857293] Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
[LiteratureReference:9857337] The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
[LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
[LiteratureReference:9857334] The T-box transcription factor Tbx2: its role in development and possible implication in cancer
[LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes
[LiteratureReference:9857304] Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture
[LiteratureReference:9857299] Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation
[LiteratureReference:9857313] Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
[LiteratureReference:9857326] Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor
[LiteratureReference:9857331] Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas
modified[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
[InstanceEdit:9857395] Rothfels, Karen, 2024-01-04
[InstanceEdit:9863248] Rothfels, Karen, 2024-02-28
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
nameMITF-M-dependent TBX2 gene expression
output[EntityWithAccessionedSequence:9825814] TBX2 [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveGeneExpressionRegulation:9825852] Positive gene expression regulation by 'MITF-M:TBX2 gene [nucleoplasm]'
regulationReference[RegulationReference:9825857] Positive gene expression regulation by 'MITF-M:TBX2 gene [nucleoplasm]' Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
releaseDate2024-03-27
reviewed[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26
[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9825870] R-HSA-9825840.3
summation[Summation:9857348] TBX2 is an MITF-M-dependent target that contributes to melan...
(hasEvent)[Pathway:9825892] Regulation of MITF-M-dependent genes involved in cell cycle and proliferation [Homo sapiens]
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No pathways have been reviewed or authored by MITF-M-dependent TBX2 gene expression (9825840)
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