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Details on Person MITF-M dimer binds the CDKN1A promoter

Class:Id	Reaction:9825835
_displayName	MITF-M dimer binds the CDKN1A promoter
_doRelease	TRUE
_timestamp	2024-11-08 15:56:24
authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9825866] Rothfels, Karen, 2023-01-27
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input	[Complex:9825710] MITF-M dimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3786256] CDKN1A gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9825809] Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression [LiteratureReference:9858449] Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor [LiteratureReference:9858486] Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma [LiteratureReference:9857178] Mitf regulation of Dia1 controls melanoma proliferation and invasiveness [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9857154] MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
modified	[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28 [InstanceEdit:9857592] Rothfels, Karen, 2024-01-07 [InstanceEdit:9858564] Rothfels, Karen, 2024-01-13 [InstanceEdit:9863246] Rothfels, Karen, 2024-02-28 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9917237] Rothfels, Karen, 2024-08-01 [InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M dimer binds the CDKN1A promoter
output	[Complex:9825860] MITF-M dimer:CDKN1A gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9857375] MITF dimerizes [Homo sapiens] [BlackBoxEvent:9730412] MITF gene expression [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9825868] R-HSA-9825835.4
summation	[Summation:9858542] MITF binds to an E-box element in the promoter of the CDKN1A...
(hasEvent)	[Pathway:9825892] Regulation of MITF-M-dependent genes involved in cell cycle and proliferation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9825837] MITF-M-dependent CDKN1A expression [Homo sapiens]
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