Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person p-S742 TBX3 binds CDH1 promoter

Class:IdReaction:9825794
_displayNamep-S742 TBX3 binds CDH1 promoter
_doReleaseTRUE
_timestamp2024-11-08 15:59:09
authored[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9825795] Rothfels, Karen, 2023-01-26
edited[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input[EntityWithAccessionedSequence:9825680] p-S742 TBX3 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimericFALSE
literatureReference[LiteratureReference:9768259] Tbx3 represses E-cadherin expression and enhances melanoma invasiveness
[LiteratureReference:9825523] The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
[LiteratureReference:9825509] TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF
[LiteratureReference:9825487] Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion
[LiteratureReference:9825526] The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion
[LiteratureReference:9825517] The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process
[LiteratureReference:9825545] The tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor
[LiteratureReference:9825539] The roles and regulation of TBX3 in development and disease
modified[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
[InstanceEdit:9863246] Rothfels, Karen, 2024-02-28
[InstanceEdit:9907153] Rothfels, Karen, 2024-04-04
[InstanceEdit:9909022] Rothfels, Karen, 2024-04-25
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
namep-S742 TBX3 binds CDH1 promoter
output[Complex:9825718] p-S742 TBX3:CDH1 gene [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2024-06-15
reviewed[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9825796] R-HSA-9825794.2
summation[Summation:9825699] TBX3 binds to the promoter of the CDH1 gene to repress its t...
(hasEvent)[Pathway:9856649] Transcriptional and post-translational regulation of MITF-M expression and activity [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by p-S742 TBX3 binds CDH1 promoter (9825794)
Follow Reactome