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Details on Person MAPK-dependent phosphorylation of KARS

Class:IdReaction:9825759
_displayNameMAPK-dependent phosphorylation of KARS
_doReleaseTRUE
_timestamp2024-11-08 15:54:40
authored[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
catalystActivity[CatalystActivity:1268259] MAP kinase activity of p-T,Y MAPK dimers [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9825761] Rothfels, Karen, 2023-01-26
edited[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input[Complex:379688] aminoacyl-tRNA synthetase multienzyme complex [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimericFALSE
literatureReference[LiteratureReference:9730403] MITF-the first 25 years
[LiteratureReference:9825455] Complex of aminoacyl-transfer RNA synthetases
[LiteratureReference:9825464] Enzymatic synthesis of diadenosine tetraphosphate and diadenosine triphosphate with a purified lysyl-sRNA synthetase
[LiteratureReference:9825507] Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells
[LiteratureReference:9825479] LysRS serves as a key signaling molecule in the immune response by regulating gene expression
[LiteratureReference:9825494] Structural switch of lysyl-tRNA synthetase between translation and transcription
[LiteratureReference:9825457] Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells
[LiteratureReference:9825529] The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells
modified[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
[InstanceEdit:9863246] Rothfels, Karen, 2024-02-28
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927680] Rothfels, Karen, 2024-11-08
nameMAPK-dependent phosphorylation of KARS
output[Complex:9825709] KARS-depleted MSC [cytosol] [Homo sapiens]
[Complex:9825714] p-S207 KARS homodimer [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveRegulation:9824980] Positive regulation by 'p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]'
regulationReference[RegulationReference:9825760] Positive regulation by 'p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]' Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells
releaseDate2024-03-27
reviewed[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26
[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9825762] R-HSA-9825759.3
summation[Summation:9825698] A link between protein translation levels and MITF signaling...
(hasEvent)[Pathway:9856649] Transcriptional and post-translational regulation of MITF-M expression and activity [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9825783] p-S207 KARS1 dimer translocates to the nucleus [Homo sapiens]
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