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Details on Person MITF-M dimer binds the BCL2 promoter

Class:Id	Reaction:9825756
_displayName	MITF-M dimer binds the BCL2 promoter
_doRelease	TRUE
_timestamp	2024-11-08 15:56:16
authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9825755] Rothfels, Karen, 2023-01-26
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input	[Complex:9825710] MITF-M dimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8948460] BCL2 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9824538] Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9858199] miR-211 and MITF modulation by Bcl-2 protein in melanoma cells
modified	[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28 [InstanceEdit:9857592] Rothfels, Karen, 2024-01-07 [InstanceEdit:9858312] Rothfels, Karen, 2024-01-10 [InstanceEdit:9863246] Rothfels, Karen, 2024-02-28 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M dimer binds the BCL2 promoter
output	[Complex:9825715] MITF-M:BCL2 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9857375] MITF dimerizes [Homo sapiens] [BlackBoxEvent:9730412] MITF gene expression [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9825758] R-HSA-9825756.3
summation	[Summation:9858294] MITF binds to an E-box element in the promoter of the BCL2 g...
(hasEvent)	[Pathway:9824594] Regulation of MITF-M-dependent genes involved in apoptosis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9824587] MITF-M-dependent BCL2 expression [Homo sapiens] [Reaction:9825754] HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter [Homo sapiens]
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