Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person ID1-4 (Inhibitor of DNA-binding) are members of the helix-lo...
| Class:Id | Summation:9825700 |
|---|---|
| _displayName | ID1-4 (Inhibitor of DNA-binding) are members of the helix-lo... |
| _timestamp | 2024-01-19 02:15:27 |
| created | [InstanceEdit:9825696] Rothfels, Karen, 2023-01-26 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 |
| text | ID1-4 (Inhibitor of DNA-binding) are members of the helix-loop-helix family of proteins that lack the basic amino acids responsible for DNA binding in basic HLH proteins. HLH domain-mediated heterodimerization of an ID protein with a basic HLH protein therefore acts as a natural dominant negative inhibitor of bHLH function by preventing DNA binding (Massari and Murre, 2000). ID proteins primarily interact with members of the E family of proteins, including E12, E47, HEB and E2-2, but also interact with other bHLH proteins. ID proteins promote cell cycle progression and cell migration, and restrict cellular senescence and the differentiation of a number of progenitor cell types, including oligodendrocytes (reviewed in Perk et al, 2005; Ling et al, 2014). ID1 and ID3 proteins also have established roles in hematopoiesis (Nogueira et al, 2000; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016). ID1 is overexpressed in melanomas and promotes invasion and motility (Straume and Akslen, 2005; Zigler et al, 2011). ID1 may promote invasiveness in melanoma cells by binding and inhibiting MITF-dependent CDH1 expression. Consistent with this model, ID1 and MITF-M have been shown to interact in osteoclast cells (Mansky et al, 2002; Lee et al, 2006). |
| (summation) | [BlackBoxEvent:9825780] TBX3-dependent ID1 gene expression [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by ID1-4 (Inhibitor of DNA-binding) are members of the helix-lo... (9825700)
