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Details on Person TBX3 binds to the promoter of the CDH1 gene to repress its t...
| Class:Id | Summation:9825699 |
|---|---|
| _displayName | TBX3 binds to the promoter of the CDH1 gene to repress its t... |
| _timestamp | 2024-01-19 02:15:38 |
| created | [InstanceEdit:9825696] Rothfels, Karen, 2023-01-26 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 |
| text | TBX3 binds to the promoter of the CDH1 gene to repress its transcription as assessed by electrophoretic mobility shift assay (EMSA), chromatin immunoprecipitation, reporter gene assays and RT-PCR (Rodriguez et al, 2008). AKT3-dependent phosphorylation of TBX3 promotes its nuclear localization, enhances its repression activity towards CDH1 and may increase its DNA binding affinity (Peres et al, 2015; Peres et al, 2021). TBX3 is overexpressed in melanoma and contributes to its migration and invasiveness, in part through regulation of CDH1 expression (Boyd et al, 2013; Peres and Prince 2013; Peres et al, 2010; Peres et al, 2017; reviewed in Khan et al, 2020). |
| (summation) | [Reaction:9825794] p-S742 TBX3 binds CDH1 promoter [Homo sapiens] |
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No pathways have been reviewed or authored by TBX3 binds to the promoter of the CDH1 gene to repress its t... (9825699)
