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Details on Person AKT3-phosphorylated TBX3 binds to the promoter of ID1 to act...
| Class:Id | Summation:9825694 |
|---|---|
| _displayName | AKT3-phosphorylated TBX3 binds to the promoter of ID1 to act... |
| _timestamp | 2024-08-01 21:03:14 |
| created | [InstanceEdit:9825696] Rothfels, Karen, 2023-01-26 |
| modified | [InstanceEdit:9859416] Rothfels, Karen, 2024-01-19 [InstanceEdit:9863222] Rothfels, Karen, 2024-02-28 [InstanceEdit:9907117] Rothfels, Karen, 2024-04-04 [InstanceEdit:9917237] Rothfels, Karen, 2024-08-01 |
| text | AKT3-phosphorylated TBX3 binds to the promoter of ID1 to activate expression, as assessed by electrophoretic mobility shift assays, chromatin immunoprecipitation and reporter gene assays (Peres et al, 2021). ID1 is a member of the ID1 - 4 family of helix-loop-helix proteins that lack the DNA binding region and consequently act as dominant negative inhibitors of other HLH-containing proteins upon heterodimerization (Massari and Murre, 2000; reviewed in Perk et al, 2005; Ling et al, 2014). In osteoclast cells, ID1 has been shown to bind to MITF, and MITF has been shown to directly activate CDH1 expression (Lee et al, 2006; Mansky et al, 2002; Dilshat et al,2021). In melanoma cells, TBX3 also upregulates ID1 expression which prevents MITF from binding and activating the CDH1 promoter (Peres et al, 2021). |
| (summation) | [Reaction:9825776] p-S742 TBX3 binds ID1 promoter [Homo sapiens] |
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