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Details on Person In the human respiratory syncytial virus (hRSV) virion, N pr...

Class:IdSummation:9825348
_displayNameIn the human respiratory syncytial virus (hRSV) virion, N pr...
_timestamp2023-11-07 05:55:40
created[InstanceEdit:9825351] Orlic-Milacic, Marija, 2023-01-25
literatureReference[LiteratureReference:9823510] The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer
[LiteratureReference:9825347] Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus
[LiteratureReference:9825417] Biochemical characterization of the respiratory syncytial virus P-P and P-N protein complexes and localization of the P protein oligomerization domain
[LiteratureReference:9838581] Biochemical characterization of the respiratory syncytial virus N0-P complex in solution
modified[InstanceEdit:9832281] Stephan, Ralf, 2023-03-30
[InstanceEdit:9834878] Orlic-Milacic, Marija, 2023-05-10
[InstanceEdit:9838135] Orlic-Milacic, Marija, 2023-06-21
[InstanceEdit:9838359] Orlic-Milacic, Marija, 2023-06-22
[InstanceEdit:9838401] Orlic-Milacic, Marija, 2023-06-22
[InstanceEdit:9838585] Orlic-Milacic, Marija, 2023-06-23
[InstanceEdit:9838854] Orlic-Milacic, Marija, 2023-06-27
[InstanceEdit:9852813] Orlic-Milacic, Marija, 2023-11-07
textIn the human respiratory syncytial virus (hRSV) virion, N protein decamers constitute ~60% of the nucleocapsid, while N protein hendecamers constitute ~40% of the nucleocapsid (Tran et al. 2007). While it was initially suggested that each N protein monomer contacts 6 or 7 nucleotides of RSV genomic RNA (Tran et al. 2007), it has been demonstrated that each N protein monomer contacts 7 nucleotides of genomic RNA (Tawar et al. 2009) and that RSV ribonucleocapsid is a left-handed helix (Bakker et al. 2013; Liljeroos et al. 2013). Taking into account the ratio of N-decamers to N-hendecamers, the number of RNA nucleotides bound by each N protein monomer, and the length of the human RSV A genome of ~15200 nt, it is estimated that 129 N-decamers and 80 N-hendecamers coat the RSV genome to form the nucleocapsid.

Formation of a complex between nascent P and nascent N proteins may prevent premature association of N proteins with viral RNA (Castagné et al. 2004; Esneau et al. 2019).
(summation)[BlackBoxEvent:9825340] N protein coats hRSV genomic (-)ssRNA [Homo sapiens]
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