Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person GATA4 is expressed in visceral endoderm and definitive endod...

Class:IdSummation:9825111
_displayNameGATA4 is expressed in visceral endoderm and definitive endod...
_timestamp2023-02-28 14:27:29
created[InstanceEdit:9825083] May, Bruce, 2023-01-23
literatureReference[LiteratureReference:9823869] Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer
[LiteratureReference:9825088] Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart
[LiteratureReference:9825115] An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo
modified[InstanceEdit:9825931] May, Bruce, 2023-01-27
[InstanceEdit:9827741] May, Bruce, 2023-02-01
[InstanceEdit:9830221] May, Bruce, 2023-02-28
[InstanceEdit:9830225] May, Bruce, 2023-02-28
textGATA4 is expressed in visceral endoderm and definitive endoderm and subsequently is enriched in the mid and posterior gut (inferred from mouse embryos in Arceci et al. 1993, Rojas et al. 2009, Rojas et al. 2010). Expression of GATA4 is activated by NODAL signaling (McLean et al. 2007, Vallier et al. 2009) through the binding of phosphorylated SMAD2 and SMAD3 to the GATA4 promoter (inferred from human pluripotent stem cells in Brown et al. 2011, Chia et al. 2019). FOXA2 (inferred from mouse homologs) and GATA6 (Chia et al. 2019), other key regulators of endoderm formation, also bind the GATA4 promoter and activate GATA4 transcription.
(summation)[BlackBoxEvent:9823849] Expression of GATA4 in definitive endoderm [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by GATA4 is expressed in visceral endoderm and definitive endod... (9825111)
Follow Reactome