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Details on Person In mouse embryos, Sox17 is first expressed in the visceral e...
| Class:Id | Summation:9825055 |
|---|---|
| _displayName | In mouse embryos, Sox17 is first expressed in the visceral e... |
| _timestamp | 2023-02-28 14:27:31 |
| created | [InstanceEdit:9825083] May, Bruce, 2023-01-23 |
| literatureReference | [LiteratureReference:9823949] SOX17 links gut endoderm morphogenesis and germ layer segregation |
| modified | [InstanceEdit:9825931] May, Bruce, 2023-01-27 [InstanceEdit:9827851] May, Bruce, 2023-02-07 [InstanceEdit:9830221] May, Bruce, 2023-02-28 [InstanceEdit:9830225] May, Bruce, 2023-02-28 |
| text | In mouse embryos, Sox17 is first expressed in the visceral endoderm, then in presumptive definitive endoderm before and during intercalation with visceral endoderm (Viotti et al. 2014). Expression of SOX17 is activated by WNT signaling via LEF1:CTNNB1 binding the SOX17 promoter (inferred from mouse homologs). During differentiation of human pluripotent stem cells to endoderm, expression of SOX17 is activated by NODAL signaling via phosphorylated SMAD2 and SMAD3 (Brown et al. 2011, Teo et al. 2011). GATA6, EOMES (Chia et al. 2019), BMP signaling (Xu et al. 2011), and MIXL1 (inferred from mouse homologs) also regulate SOX17. |
| (summation) | [BlackBoxEvent:9823729] Expression of SOX17 in definitive endoderm [Homo sapiens] |
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No pathways have been reviewed or authored by In mouse embryos, Sox17 is first expressed in the visceral e... (9825055)
