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Details on Person GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405

Class:Id	Reaction:9824995
_displayName	GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405
_doRelease	TRUE
_timestamp	2024-11-08 15:49:44
authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
catalystActivity	[CatalystActivity:2022841] protein serine/threonine kinase activity of GSK3B [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9824976] Rothfels, Karen, 2023-01-23
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
input	[EntityWithAccessionedSequence:9824967] p-S409 MITF-M [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9824946] c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi [LiteratureReference:9824935] MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9824912] BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export
modified	[InstanceEdit:9863246] Rothfels, Karen, 2024-02-28 [InstanceEdit:9863567] Matthews, Lisa, 2024-03-04 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9917237] Rothfels, Karen, 2024-08-01 [InstanceEdit:9927674] Rothfels, Karen, 2024-11-08
name	GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405
output	[EntityWithAccessionedSequence:9824963] p-S397,401,405,409 MITF-M [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:9824994] RPS6KA1-dependent phosphorylation of MITF-M [Homo sapiens] [BlackBoxEvent:9730412] MITF gene expression [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:9824993] Negative regulation by 'N4GlycoAsn-PalmS WNT3A [extracellular region]'
regulationReference	[RegulationReference:9824997] Negative regulation by 'N4GlycoAsn-PalmS WNT3A [extracellular region]' MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9825005] R-HSA-9824995.4
summation	[Summation:9824989] RPS6KA1-dependent phosphorylation of MITF-M at serine 409 pr...
(hasEvent)	[Pathway:9856649] Transcriptional and post-translational regulation of MITF-M expression and activity [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9919474] Update Tracker - [Reaction:9824995] GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 - v90:[modifyText, removeLiteratureReference]
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