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Details on Person RPS6KA1-dependent phosphorylation of MITF-M at serine 409 pr...
| Class:Id | Summation:9824989 |
|---|---|
| _displayName | RPS6KA1-dependent phosphorylation of MITF-M at serine 409 pr... |
| _timestamp | 2024-08-01 21:03:57 |
| created | [InstanceEdit:9824976] Rothfels, Karen, 2023-01-23 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 [InstanceEdit:9863222] Rothfels, Karen, 2024-02-28 [InstanceEdit:9917237] Rothfels, Karen, 2024-08-01 |
| text | RPS6KA1-dependent phosphorylation of MITF-M at serine 409 primes the protein for subsequent phosphorylations at three sites in the C-terminal region by GSK3B. Mutation of serine residues at S397, S401 and S405 to alanine increases the stability of MITF-M, suggesting a role for GSK3B in degradation of the protein. Consistent with this, WNT3A treatment, which inactivates GSK3B, increases MITF-M stability and increases its transcription factor activity towards target gene MART1 in the melanoma cell line M308 (Wu et al, 2000; Ploper et al, 2015; reviewed in Goding and Arnheiter, 2019). Note however that this effect may also be the result of WNT3A-dependent abrogation of GSK3B-dependent phosphorylation at S69 and subsequent nuclear export, as described (Ngeow et al, 2018). |
| (summation) | [Reaction:9824995] GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 [Homo sapiens] |
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No pathways have been reviewed or authored by RPS6KA1-dependent phosphorylation of MITF-M at serine 409 pr... (9824989)
