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Details on Person GSK3B-dependent phosphorylation of MITF-M at residue S69 pro...
| Class:Id | Summation:9824982 |
|---|---|
| _displayName | GSK3B-dependent phosphorylation of MITF-M at residue S69 pro... |
| _timestamp | 2024-08-01 21:03:19 |
| created | [InstanceEdit:9824976] Rothfels, Karen, 2023-01-23 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 [InstanceEdit:9863222] Rothfels, Karen, 2024-02-28 [InstanceEdit:9917237] Rothfels, Karen, 2024-08-01 |
| text | GSK3B-dependent phosphorylation of MITF-M at residue S69 promotes its interaction with the nuclear export factor XPO1, also known as CRM1 (Ngeow et al, 2018). Nuclear export of MITF-M is dependent on the nuclear export sequence MxMLxM located at residues 74-80. Mutation of this site abrogates nuclear export of an MITF-M reporter in response to MAPK activation by TPA (12-O-tetradecanoylphorbol-13 acetate), supporting a model where sequential phosphorylations by MAPK1 and GSK3B at MITF-M serine residues S73 and S69 promote XPO1-dependent relocation of MITF-M to the cytosol (Ngeow et al, 2018; reviewed in Goding and Arnheiter, 2019). MITF-M has also been shown to interact with other nuclear pore export factors including KPNA1, KPNB1, KPNA4, NUP50, NUP153, NPM1, NOP14, TNPO1 and XPO5, reflecting regulation of MITF localization and/or a tethering of MITF transcription factor activity with RNA export (Laurette et al, 2015). |
| (summation) | [Reaction:9824979] XPO1 binds p-S69,73 MITF-M [Homo sapiens] |
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No pathways have been reviewed or authored by GSK3B-dependent phosphorylation of MITF-M at residue S69 pro... (9824982)
