Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person OPTN recruits CYLD to the TNFR1 complex

Class:IdReaction:9824874
_displayNameOPTN recruits CYLD to the TNFR1 complex
_doReleaseTRUE
_timestamp2023-03-06 23:42:30
authored[InstanceEdit:9824872] Shamovsky, Veronica, 2023-01-23
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9824872] Shamovsky, Veronica, 2023-01-23
edited[InstanceEdit:9830261] Shamovsky, Veronica, 2023-03-01
input[Complex:9793672] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:741420] CYLD [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9827600] Matthews, Lisa, 2023-01-31
literatureReference[LiteratureReference:9823788] Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation
modified[InstanceEdit:9825237] Shamovsky, Veronica, 2023-01-24
[InstanceEdit:9827631] Shamovsky, Veronica, 2023-01-31
[InstanceEdit:9828537] Shamovsky, Veronica, 2023-02-15
[InstanceEdit:9829018] Shamovsky, Veronica, 2023-02-21
[InstanceEdit:9830261] Shamovsky, Veronica, 2023-03-01
[InstanceEdit:9830339] Shamovsky, Veronica, 2023-03-06
nameOPTN recruits CYLD to the TNFR1 complex
output[Complex:9824875] CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2023-03-29
reviewed[InstanceEdit:9828415] Munitić, Ivana, 2023-02-14
[InstanceEdit:9830259] Franjkić, Toni, 2023-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9824877] R-HSA-9824874.1
summation[Summation:9824873] Optineurin (OPTN) is a multifunctional, ubiquitin-binding ad...
(hasEvent)[Pathway:5357905] Regulation of TNFR1 signaling [Homo sapiens]
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No pathways have been reviewed or authored by OPTN recruits CYLD to the TNFR1 complex (9824874)