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Details on Person MITF-M-dependent BCL2 expression

Class:IdBlackBoxEvent:9824587
_displayNameMITF-M-dependent BCL2 expression
_doReleaseTRUE
_timestamp2024-11-08 15:56:59
authored[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
compartment[Compartment:13231] nuclear envelope
[Compartment:17906] mitochondrial outer membrane
created[InstanceEdit:9824591] Rothfels, Karen, 2023-01-20
edited[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input[EntityWithAccessionedSequence:8948460] BCL2 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimericFALSE
literatureReference[LiteratureReference:9824538] Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
[LiteratureReference:9825671] The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
[LiteratureReference:9858346] Accelerated disappearance of melanocytes in bcl-2-deficient mice
[LiteratureReference:9858368] Bcl-2 overexpression in melanoma cells increases tumor progression-associated properties and in vivo tumor growth
[LiteratureReference:9858373] Apoptosis and melanoma chemoresistance
[LiteratureReference:9825159] Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?
[LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes
[LiteratureReference:9730403] MITF-the first 25 years
[LiteratureReference:9858199] miR-211 and MITF modulation by Bcl-2 protein in melanoma cells
modified[InstanceEdit:9825803] Rothfels, Karen, 2023-01-26
[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
[InstanceEdit:9855907] Rothfels, Karen, 2023-12-07
[InstanceEdit:9858312] Rothfels, Karen, 2024-01-10
[InstanceEdit:9858409] Rothfels, Karen, 2024-01-12
[InstanceEdit:9863248] Rothfels, Karen, 2024-02-28
[InstanceEdit:9863252] Rothfels, Karen, 2024-02-28
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
nameMITF-M-dependent BCL2 expression
output[EntityWithAccessionedSequence:50757] BCL2 [mitochondrial outer membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveGeneExpressionRegulation:9825744] Positive gene expression regulation by 'MITF-M:BCL2 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9825742] Negative gene expression regulation by 'HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm]'
regulationReference[RegulationReference:9825768] Positive gene expression regulation by 'MITF-M:BCL2 gene [nucleoplasm]' Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
[RegulationReference:9825765] Negative gene expression regulation by 'HINT1:MITF-M:BCL2 gene [nucleoplasm]' The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells
releaseDate2024-03-27
reviewed[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26
[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9824607] R-HSA-9824587.3
summation[Summation:9858296] MITF binds to the promoter of the BCL2 gene to upregulate it...
(hasEvent)[Pathway:9824594] Regulation of MITF-M-dependent genes involved in apoptosis [Homo sapiens]
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No pathways have been reviewed or authored by MITF-M-dependent BCL2 expression (9824587)
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