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Details on Person MAPK1 phosphorylates SOX10

Class:IdReaction:9824582
_displayNameMAPK1 phosphorylates SOX10
_doReleaseTRUE
_timestamp2024-11-08 15:54:42
authored[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
catalystActivity[CatalystActivity:9619970] protein serine/threonine kinase activity of p-T185,Y187 MAPK1 dimer [cytosol]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9824591] Rothfels, Karen, 2023-01-20
edited[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
input[EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens]
[SimpleEntity:29358] ATP [nucleoplasm]
[SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimericFALSE
literatureReference[LiteratureReference:9824528] ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma
[LiteratureReference:9907098] MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells
modified[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
[InstanceEdit:9863246] Rothfels, Karen, 2024-02-28
[InstanceEdit:9863251] Rothfels, Karen, 2024-02-28
[InstanceEdit:9907153] Rothfels, Karen, 2024-04-04
[InstanceEdit:9909022] Rothfels, Karen, 2024-04-25
[InstanceEdit:9910861] Rothfels, Karen, 2024-05-21
[InstanceEdit:9927680] Rothfels, Karen, 2024-11-08
nameMAPK1 phosphorylates SOX10
output[EntityWithAccessionedSequence:9824578] p-T240,T244-SOX10 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113582] ADP [nucleoplasm]
[SimpleEntity:113582] ADP [nucleoplasm]
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2024-06-15
reviewed[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21
[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05
[InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9824602] R-HSA-9824582.2
summation[Summation:9824590] SOX10 is phosphorylated by MAPK1 (ERK2) at threonine residue...
(hasEvent)[Pathway:9856649] Transcriptional and post-translational regulation of MITF-M expression and activity [Homo sapiens]
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No pathways have been reviewed or authored by MAPK1 phosphorylates SOX10 (9824582)