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Details on Person Expression of GATA6 in definitive endoderm

Class:IdBlackBoxEvent:9823977
_displayNameExpression of GATA6 in definitive endoderm
_doReleaseTRUE
_timestamp2023-02-28 14:51:04
authored[InstanceEdit:9823884] May, Bruce, 2023-01-11
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9823972] May, Bruce, 2023-01-13
edited[InstanceEdit:9823884] May, Bruce, 2023-01-11
input[EntityWithAccessionedSequence:2888975] GATA6 gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
[LiteratureReference:9824465] GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation
[LiteratureReference:9825100] Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed
[LiteratureReference:9825097] Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways
modified[InstanceEdit:9824489] May, Bruce, 2023-01-20
[InstanceEdit:9825124] May, Bruce, 2023-01-23
[InstanceEdit:9830227] May, Bruce, 2023-02-28
nameExpression of GATA6 in definitive endoderm
output[EntityWithAccessionedSequence:452902] GATA6 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveGeneExpressionRegulation:9824483] Positive gene expression regulation by 'p-2S-SMAD2,3:GATA6-AS1 lncRNA:GATA6 gene [nucleoplasm]'
regulationReference[RegulationReference:9824485] Positive gene expression regulation by 'p-2S-SMAD2,3:GATA6 gene [nucleoplasm]' Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
releaseDate2023-03-29
reviewed[InstanceEdit:9830224] Salehin, Nazmus, 2023-02-28
[InstanceEdit:9830223] Tam, Patrick P L, 2023-02-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9824018] R-HSA-9823977.1
summation[Summation:9825030] In mouse embryos, Gata6 is expressed in the primitive streak...
(hasEvent)[Pathway:9823730] Formation of definitive endoderm [Homo sapiens]
(precedingEvent)[Reaction:9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene [Homo sapiens]
[Reaction:9823952] EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene [Homo sapiens]
[Reaction:9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene [Homo sapiens]
[Reaction:9823964] EOMES, SMAD2,3, and GATA6 bind the LHX1 gene [Homo sapiens]
[Reaction:9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene [Homo sapiens]
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