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Details on Person EOMES, SMAD2,3, and GATA6 bind the LHX1 gene

Class:Id	Reaction:9823964
_displayName	EOMES, SMAD2,3, and GATA6 bind the LHX1 gene
_timestamp	2023-01-23 18:27:38
authored	[InstanceEdit:9823884] May, Bruce, 2023-01-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823972] May, Bruce, 2023-01-13
edited	[InstanceEdit:9823884] May, Bruce, 2023-01-11
inferredFrom	[Reaction:9825102] Eomes binds the Lhx1 gene [Mus musculus]
input	[EntityWithAccessionedSequence:452232] EOMES [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452902] GATA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9761179] LHX1 gene [nucleoplasm] [Homo sapiens] [DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9823982] GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation [LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin
modified	[InstanceEdit:9825124] May, Bruce, 2023-01-23
name	EOMES, SMAD2,3, and GATA6 bind the LHX1 gene
output	[Complex:9823994] EOMES:p-2S-SMAD2,3:SMAD4:GATA6:LHX1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:452353] Expression of EOMES in the primitive streak [Homo sapiens] [Reaction:9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene [Homo sapiens] [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens] [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens] [BlackBoxEvent:9823977] Expression of GATA6 in definitive endoderm [Homo sapiens] [Reaction:9823959] SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9824003] R-HSA-9823964.1
summation	[Summation:9825049] NODAL signaling in the anterior primitive streak causes phos...
(precedingEvent)	[BlackBoxEvent:9823953] Expression of LHX1 in endoderm [Homo sapiens]
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No pathways have been reviewed or authored by EOMES, SMAD2,3, and GATA6 bind the LHX1 gene (9823964)