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Details on Person EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]

Class:Id	Complex:9823963
_displayName	EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]
_timestamp	2023-01-31 18:49:52
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823972] May, Bruce, 2023-01-13
hasComponent	[DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452232] EOMES [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9796194] FOXA2 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452902] GATA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452976] TBXT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9827604] DEANR1 lncRNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:9823982] GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation [LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:9796288] The lncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression
modified	[InstanceEdit:9824489] May, Bruce, 2023-01-20 [InstanceEdit:9827632] May, Bruce, 2023-01-31
name	EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9824008] R-HSA-9823963.1
(output)	[Reaction:9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene [Homo sapiens]
(regulator)	[PositiveGeneExpressionRegulation:9823997] Positive gene expression regulation by 'EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm]'
(updatedInstance)	[_UpdateTracker:9906103] Update Tracker - [Complex:9823963] EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] - v86:[updateContainedComponent]
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No pathways have been reviewed or authored by EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (9823963)