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Details on Person EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene

Class:Id	Reaction:9823958
_displayName	EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene
_doRelease	TRUE
_timestamp	2023-02-28 14:50:43
authored	[InstanceEdit:9823884] May, Bruce, 2023-01-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9823972] May, Bruce, 2023-01-13
edited	[InstanceEdit:9823884] May, Bruce, 2023-01-11
inferredFrom	[Reaction:9824464] Tbxt (Brachyury) binds the Foxa2 gene [Mus musculus]
input	[EntityWithAccessionedSequence:452232] EOMES [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9796194] FOXA2 gene [nucleoplasm] [Homo sapiens] [DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452902] GATA6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:452976] TBXT [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9827604] DEANR1 lncRNA [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin [LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors [LiteratureReference:9823982] GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation [LiteratureReference:9796288] The lncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression [LiteratureReference:9757591] Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells [LiteratureReference:9824500] DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells
modified	[InstanceEdit:9824489] May, Bruce, 2023-01-20 [InstanceEdit:9825124] May, Bruce, 2023-01-23 [InstanceEdit:9827632] May, Bruce, 2023-01-31 [InstanceEdit:9830221] May, Bruce, 2023-02-28 [InstanceEdit:9830227] May, Bruce, 2023-02-28
name	EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene
output	[Complex:9823963] EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens] [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens] [BlackBoxEvent:452353] Expression of EOMES in the primitive streak [Homo sapiens] [Reaction:9754480] p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene [Homo sapiens] [BlackBoxEvent:9823977] Expression of GATA6 in definitive endoderm [Homo sapiens] [Reaction:9823959] SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene [Homo sapiens]
releaseDate	2023-03-29
reviewed	[InstanceEdit:9830224] Salehin, Nazmus, 2023-02-28 [InstanceEdit:9830223] Tam, Patrick P L, 2023-02-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9823998] R-HSA-9823958.1
summation	[Summation:9825073] In mouse embryos, Foxa2 is expressed in the posterior epibla...
(hasEvent)	[Pathway:9823730] Formation of definitive endoderm [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9823989] Expression of FOXA2 in definitive endoderm [Homo sapiens]
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No pathways have been reviewed or authored by EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (9823958)