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Details on Person Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Class:Id	Reaction:9823910
_displayName	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
_doRelease	TRUE
_timestamp	2024-03-01 04:17:00
authored	[InstanceEdit:9823790] Shamovsky, Veronica, 2023-01-10
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9823907] Shamovsky, Veronica, 2023-01-12
edited	[InstanceEdit:9863317] Shamovsky, Veronica, 2024-02-28
input	[Complex:5362507] K63pUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:166267] TBK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166267] TBK1 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9832591] D'Eustachio, Peter, 2023-04-03 [InstanceEdit:9839728] Matthews, Lisa, 2023-07-10
isChimeric	FALSE
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:5362611] Structure and ubiquitination-dependent activation of TANK-binding kinase 1
modified	[InstanceEdit:9823946] Shamovsky, Veronica, 2023-01-12 [InstanceEdit:9832589] Shamovsky, Veronica, 2023-04-03 [InstanceEdit:9839731] Shamovsky, Veronica, 2023-07-10 [InstanceEdit:9862122] Shamovsky, Veronica, 2024-02-23 [InstanceEdit:9863311] Shamovsky, Veronica, 2024-02-28 [InstanceEdit:9863523] Shamovsky, Veronica, 2024-03-01
name	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
output	[Complex:9823899] TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens]
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863305] Munitić, Ivana, 2024-02-28 [InstanceEdit:9863304] Franjkić, Toni, 2024-02-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9823927] R-HSA-9823910.1
summation	[Summation:9823915] Upon stimulation by pathogen-associated inflammatory signals...
(hasEvent)	[Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9823904] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens] [Reaction:9823906] TBK1 is phosphorylated within the activated TLR4 complex [Homo sapiens] [Reaction:9823934] OPTN binds TBK1 within the activated TLR4 complex [Homo sapiens]
(replacementInstances)	[_Deleted:9863359] Deletion of instance: 936941
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No pathways have been reviewed or authored by Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (9823910)