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Details on Person TBK1 is phosphorylated within the activated TLR4 complex

Class:Id	Reaction:9823906
_displayName	TBK1 is phosphorylated within the activated TLR4 complex
_doRelease	TRUE
_timestamp	2024-03-01 04:17:04
authored	[InstanceEdit:9823790] Shamovsky, Veronica, 2023-01-10
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9823907] Shamovsky, Veronica, 2023-01-12
edited	[InstanceEdit:9863317] Shamovsky, Veronica, 2024-02-28
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:9823899] TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9832591] D'Eustachio, Peter, 2023-04-03 [InstanceEdit:9839728] Matthews, Lisa, 2023-07-10
isChimeric	FALSE
literatureReference	[LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:166859] IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway [LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases [LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1
modified	[InstanceEdit:9823946] Shamovsky, Veronica, 2023-01-12 [InstanceEdit:9824887] Shamovsky, Veronica, 2023-01-23 [InstanceEdit:9827940] Shamovsky, Veronica, 2023-02-09 [InstanceEdit:9832589] Shamovsky, Veronica, 2023-04-03 [InstanceEdit:9839731] Shamovsky, Veronica, 2023-07-10 [InstanceEdit:9862122] Shamovsky, Veronica, 2024-02-23 [InstanceEdit:9863311] Shamovsky, Veronica, 2024-02-28 [InstanceEdit:9863523] Shamovsky, Veronica, 2024-03-01
name	TBK1 is phosphorylated within the activated TLR4 complex TBK1 is phosphorylated within TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:9823900] p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent	[Reaction:9823910] Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens] [BlackBoxEvent:5362500] TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 [Homo sapiens]
regulatedBy	[PositiveRegulation:9823947] Positive regulation by 'OPTN:TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [plasma membrane]'
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863305] Munitić, Ivana, 2024-02-28 [InstanceEdit:9863304] Franjkić, Toni, 2024-02-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9823926] R-HSA-9823906.1
summation	[Summation:9823911] TANK-binding kinase I (TBK1) and its close homolog inhibitor...
(hasEvent)	[Pathway:936964] Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) [Homo sapiens]
(precedingEvent)	[Reaction:166271] IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 [Homo sapiens]
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No pathways have been reviewed or authored by TBK1 is phosphorylated within the activated TLR4 complex (9823906)