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Details on Person TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4

Class:IdBlackBoxEvent:9823904
_displayNameTBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
_doReleaseTRUE
_timestamp2024-03-01 04:17:06
authored[InstanceEdit:9823790] Shamovsky, Veronica, 2023-01-10
compartment[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created[InstanceEdit:9823907] Shamovsky, Veronica, 2023-01-12
edited[InstanceEdit:9863317] Shamovsky, Veronica, 2024-02-28
input[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[Complex:9823899] TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9832591] D'Eustachio, Peter, 2023-04-03
[InstanceEdit:9839728] Matthews, Lisa, 2023-07-10
isChimericFALSE
literatureReference[LiteratureReference:433880] Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
[LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1
[LiteratureReference:5362611] Structure and ubiquitination-dependent activation of TANK-binding kinase 1
[LiteratureReference:9705328] IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex
modified[InstanceEdit:9823946] Shamovsky, Veronica, 2023-01-12
[InstanceEdit:9832589] Shamovsky, Veronica, 2023-04-03
[InstanceEdit:9839731] Shamovsky, Veronica, 2023-07-10
[InstanceEdit:9862122] Shamovsky, Veronica, 2024-02-23
[InstanceEdit:9863311] Shamovsky, Veronica, 2024-02-28
[InstanceEdit:9863523] Shamovsky, Veronica, 2024-03-01
nameTBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4
output[Complex:9823909] K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Homo sapiens]
precedingEvent
releaseDate2024-03-27
reviewed[InstanceEdit:9863305] Munitić, Ivana, 2024-02-28
[InstanceEdit:9863304] Franjkić, Toni, 2024-02-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9823919] R-HSA-9823904.1
summation[Summation:9823901] Pathogen‑associated inflammatory signaling pathways result i...
(hasEvent)[Pathway:9824878] Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 [Homo sapiens]
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