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Details on Person KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)

Class:Id	Reaction:9822985
_displayName	KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)
_doRelease	TRUE
_timestamp	2026-03-13 14:28:49
authored	[InstanceEdit:9822777] May, Bruce, 2022-12-28
catalystActivity	[CatalystActivity:5617989] histone H3K27me2/H3K27me3 demethylase activity of KDM6A:Fe2+ [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9822949] May, Bruce, 2023-01-03
crossReference	[DatabaseIdentifier:9985018] RHEA:60225
edited	[InstanceEdit:9822777] May, Bruce, 2022-12-28
inferredFrom	[Reaction:9822964] Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3) [Mus musculus]
input	[DefinedSet:212266] Histone H3 (H3K27me3) [nucleoplasm] [Homo sapiens] [SimpleEntity:113671] 2OG [nucleoplasm] [SimpleEntity:113671] 2OG [nucleoplasm] [SimpleEntity:113685] O2 [nucleoplasm] [SimpleEntity:113685] O2 [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9822973] Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases [LiteratureReference:4687075] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development
modified	[InstanceEdit:9823275] May, Bruce, 2023-01-05 [InstanceEdit:9827267] May, Bruce, 2023-01-31 [InstanceEdit:9841053] May, Bruce, 2023-08-07 [InstanceEdit:9841067] May, Bruce, 2023-08-08 [InstanceEdit:9984987] Stephan, Ralf, 2026-03-13
name	KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)
output	[DefinedSet:9822946] Histone H3 (H3K27me1) [nucleoplasm] [Homo sapiens] [SimpleEntity:159942] CO2 [nucleoplasm] [SimpleEntity:159942] CO2 [nucleoplasm] [SimpleEntity:29478] CH2O [nucleoplasm] [SimpleEntity:29478] CH2O [nucleoplasm] [SimpleEntity:159939] SUCCA [nucleoplasm] [SimpleEntity:159939] SUCCA [nucleoplasm]
releaseDate	2023-09-13
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9823007] R-HSA-9822985.1
summation	[Summation:9822915] KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K2...
(hasEvent)	[Pathway:9821002] Chromatin modifications during the maternal to zygotic transition (MZT) [Homo sapiens]
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No pathways have been reviewed or authored by KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3) (9822985)